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Type: Artigo de periódico
Title: Hypoadiponectinemia And Aldosterone Excess Are Associated With Lack Of Blood Pressure Control In Subjects With Resistant Hypertension.
Author: de Faria, Ana P C
Demacq, Caroline
Figueiredo, Valéria N
Moraes, Carolina H
Santos, Rodrigo C
Sabbatini, Andréa R
Barbaro, Natália R
Boer-Martins, Leandro
Fontana, Vanessa
Moreno, Heitor
Abstract: Obesity, arterial stiffness and high aldosterone levels can interact to cause resistant hypertension (RHTN). Lower adiponectin (APN) levels may be significantly associated with hypertension. However, the importance of hypoadiponectinemia as a complicating factor in the lack of blood pressure (BP) control in individuals with RHTN has not been demonstrated. Ninety-six RHTN patients were classified into uncontrolled (UCRHTN, n = 44) and controlled (CRHTN, n = 52) subgroups. Their APN and aldosterone levels, office and ambulatory BP (ABPM) measurements, endothelium-dependent brachial artery responses (flow-mediated dilation (FMD)), left ventricular mass index (LVMI) and pulse wave velocity (PWV) were evaluated. The UCRHTN subgroup had increased aldosterone levels, as well as higher LVMI and PWV. In addition, lower APN levels and impaired FMD response were found in this subgroup. The brachial and ABPM pulse pressures were inversely associated with the APN levels (r = -0.45, P = 0.002; r = -0.33, P = 0.03, respectively), as were the aldosterone levels and the PWV (r = -0.38, P = 0.01; r = -0.36, P = 0.02, respectively) in UCRHTN patients. The PWV was only significantly influenced by the APN level in the UCRHTN subgroup in the multivariate regression analysis. None of the correlations mentioned above were observed in the CRHTN subgroup. Hypoadiponectinemia and high aldosterone levels may therefore be implicated in resistance to antihypertensive therapy related to arterial stiffness.
Subject: Adiponectin
Age Factors
Blood Chemical Analysis
Blood Pressure
Blood Pressure Monitoring, Ambulatory
Body Mass Index
Cross-sectional Studies
Disease Progression
Drug Resistance
Endothelium, Vascular
Linear Models
Middle Aged
Sex Factors
Citation: Hypertension Research : Official Journal Of The Japanese Society Of Hypertension. v. 36, n. 12, p. 1067-72, 2013-Dec.
Rights: aberto
Identifier DOI: 10.1038/hr.2013.92
Date Issue: 2013
Appears in Collections:Unicamp - Artigos e Outros Documentos

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