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dc.contributor.CRUESPUNIVERSIDADE DE ESTADUAL DE CAMPINASpt_BR
dc.typeArtigo de periódicopt_BR
dc.titleAcute Exercise Suppresses Hypothalamic Ptp1b Protein Level And Improves Insulin And Leptin Signaling In Obese Rats.pt_BR
dc.contributor.authorChiarreotto-Ropelle, Eloize Cpt_BR
dc.contributor.authorPauli, Luciana S Spt_BR
dc.contributor.authorKatashima, Carlos Kpt_BR
dc.contributor.authorPimentel, Gustavo Dpt_BR
dc.contributor.authorPicardi, Paty Kpt_BR
dc.contributor.authorSilva, Vagner R Rpt_BR
dc.contributor.authorde Souza, Claudio Tpt_BR
dc.contributor.authorPrada, Patrícia Opt_BR
dc.contributor.authorCintra, Dennys Ept_BR
dc.contributor.authorCarvalheira, José B Cpt_BR
dc.contributor.authorRopelle, Eduardo Rpt_BR
dc.contributor.authorPauli, José Rpt_BR
unicamp.authorEloize C Chiarreotto-Ropelle, School of Applied Science, University of Campinas (UNICAMP Limeira, São Paulo, Brazil.pt_BR
unicamp.author.externalLuciana S S Pauli,pt
unicamp.author.externalCarlos K Katashima,pt
unicamp.author.externalGustavo D Pimentel,pt
unicamp.author.externalPaty K Picardi,pt
unicamp.author.externalVagner R R Silva,pt
unicamp.author.externalClaudio T de Souza,pt
unicamp.author.externalPatrícia O Prada,pt
unicamp.author.externalDennys E Cintra,pt
unicamp.author.externalJosé B C Carvalheira,pt
unicamp.author.externalEduardo R Ropelle,pt
unicamp.author.externalJosé R Pauli,pt
dc.subjectAnimalspt_BR
dc.subjectBlotting, Westernpt_BR
dc.subjectCorticosteronept_BR
dc.subjectHypothalamuspt_BR
dc.subjectImmunohistochemistrypt_BR
dc.subjectInflammationpt_BR
dc.subjectInsulinpt_BR
dc.subjectInterleukin-6pt_BR
dc.subjectLeptinpt_BR
dc.subjectMalept_BR
dc.subjectMicept_BR
dc.subjectMice, Obesept_BR
dc.subjectObesitypt_BR
dc.subjectPhysical Conditioning, Animalpt_BR
dc.subjectProtein Tyrosine Phosphatase, Non-receptor Type 1pt_BR
dc.subjectRandom Allocationpt_BR
dc.subjectRatspt_BR
dc.subjectRats, Wistarpt_BR
dc.subjectSignal Transductionpt_BR
dc.subjectSpecific Pathogen-free Organismspt_BR
dc.subjectExercisept_BR
dc.subjectHypothalamuspt_BR
dc.subjectInsulinpt_BR
dc.subjectLeptinpt_BR
dc.subjectObesitypt_BR
dc.description.abstractHypothalamic inflammation is associated with insulin and leptin resistance, hyperphagia, and obesity. In this scenario, hypothalamic protein tyrosine phosphatase 1B (PTP1B) has emerged as the key phosphatase induced by inflammation that is responsible for the central insulin and leptin resistance. Here, we demonstrated that acute exercise reduced inflammation and PTP1B protein level/activity in the hypothalamus of obese rodents. Exercise disrupted the interaction between PTP1B with proteins involved in the early steps of insulin (IRβ and IRS-1) and leptin (JAK2) signaling, increased the tyrosine phosphorylation of these molecules, and restored the anorexigenic effects of insulin and leptin in obese rats. Interestingly, the anti-inflammatory action and the reduction of PTP1B activity mediated by exercise occurred in an interleukin-6 (IL-6)-dependent manner because exercise failed to reduce inflammation and PTP1B protein level after the disruption of hypothalamic-specific IL-6 action in obese rats. Conversely, intracerebroventricular administration of recombinant IL-6 reproduced the effects of exercise, improving hypothalamic insulin and leptin action by reducing the inflammatory signaling and PTP1B activity in obese rats at rest. Taken together, our study reports that physical exercise restores insulin and leptin signaling, at least in part, by reducing hypothalamic PTP1B protein level through the central anti-inflammatory response.en
dc.relation.ispartofAmerican Journal Of Physiology. Endocrinology And Metabolismpt_BR
dc.relation.ispartofabbreviationAm. J. Physiol. Endocrinol. Metab.pt_BR
dc.date.issued2013-Seppt_BR
dc.identifier.citationAmerican Journal Of Physiology. Endocrinology And Metabolism. v. 305, n. 5, p. E649-59, 2013-Sep.pt_BR
dc.language.isoengpt_BR
dc.description.volume305pt_BR
dc.description.firstpageE649-59pt_BR
dc.rightsfechadopt_BR
dc.sourcePubMedpt_BR
dc.identifier.issn1522-1555pt_BR
dc.identifier.doi10.1152/ajpendo.00272.2013pt_BR
dc.identifier.urlhttp://www.ncbi.nlm.nih.gov/pubmed/23880311pt_BR
dc.date.available2015-11-27T13:31:59Z-
dc.date.accessioned2015-11-27T13:31:59Z-
dc.description.provenanceMade available in DSpace on 2015-11-27T13:31:59Z (GMT). No. of bitstreams: 1 pmed_23880311.pdf: 957210 bytes, checksum: e0cc4a0640f035da126d9cf4dc1dfdef (MD5) Previous issue date: 2013en
dc.identifier.urihttp://repositorio.unicamp.br/jspui/handle/REPOSIP/200744-
dc.identifier.idPubmed23880311pt_BR
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