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Type: Artigo de periódico
Title: Impact Of Seasonality On The Prevalence Of Dyslipidemia: A Large Population Study.
Author: Moura, Filipe A
Dutra-Rodrigues, Marcelo S
Cassol, Angela S
Parra, Eliane S
Zago, Vanessa H S
Panzoldo, Natalia B
Alexandre, Fernanda
Vieira, Isabela C
Vendrame, Felipe
Virginio, Vitor W
Castanho, Vera S
Danelon, Mirian R G
Nunes, Valeria S
Leança, Camila C
Saraiva, Francisco K
Coelho, Otavio R
Nakandakare, Edna
Quintão, Eder C R
de Faria, Eliana Cotta
Sposito, Andrei C
Abstract: Assessment of lipid profile parameters has been considered a cornerstone in classifying individuals and populations at risk for cardiovascular disease. Recently, however, preliminary data have raised the possibility of seasonal variations in these parameters, which may cause under- or overestimation. Biological rhythms and seasonal variation of lipid profile was investigated in 227 359 consecutive individuals who underwent health checkups in primary care centers between 2008 and 2010. Plasma low-density lipoprotein cholesterol (LDL-C) >130 mg/dL was 8% more prevalent during winter than summer, with a larger difference among women and middle-aged adults (p < 0.001). High-density lipoprotein cholesterol (HDL-C) <40 mg/dL and triglycerides (TG) >150 mg/dL were respectively 9% and 5% more prevalent during the summer (p < 0.001). Variation amplitude was 3.4 ± 0.3 mg/dL for HDL-C (p = 0.005), 7 ± 2 mg/dL for LDL-C (p = 0.047), and 12 ± 9 mg/dL for TG (p = 0.058). Based on a large population sample, this study confirms the existence of biological rhythms and seasonal variation in lipid profile. This finding must be particularly accounted for in cross-sectional analyses of relative risk, prevalence, or the rate of goal achievement for lipid parameters.
Subject: Adolescent
Age Distribution
Age Factors
Aged, 80 And Over
Biological Markers
Child, Preschool
Cholesterol, Hdl
Cholesterol, Ldl
Cross-sectional Studies
Infant, Newborn
Middle Aged
Nonlinear Dynamics
Risk Factors
Sex Distribution
Sex Factors
Time Factors
Young Adult
Citation: Chronobiology International. v. 30, n. 8, p. 1011-5, 2013-Oct.
Rights: fechado
Identifier DOI: 10.3109/07420528.2013.793698
Date Issue: 2013
Appears in Collections:Unicamp - Artigos e Outros Documentos

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