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Type: Artigo de periódico
Title: The Genome Of Anopheles Darlingi, The Main Neotropical Malaria Vector.
Author: Marinotti, Osvaldo
Cerqueira, Gustavo C
de Almeida, Luiz Gonzaga Paula
Ferro, Maria Inês Tiraboschi
Loreto, Elgion Lucio da Silva
Zaha, Arnaldo
Teixeira, Santuza M R
Wespiser, Adam R
Almeida E Silva, Alexandre
Schlindwein, Aline Daiane
Pacheco, Ana Carolina Landim
Silva, Artur Luiz da Costa da
Graveley, Brenton R
Walenz, Brian P
Lima, Bruna de Araujo
Ribeiro, Carlos Alexandre Gomes
Nunes-Silva, Carlos Gustavo
de Carvalho, Carlos Roberto
Soares, Célia Maria de Almeida
de Menezes, Claudia Beatriz Afonso
Matiolli, Cleverson
Caffrey, Daniel
Araújo, Demetrius Antonio M
de Oliveira, Diana Magalhães
Golenbock, Douglas
Grisard, Edmundo Carlos
Fantinatti-Garboggini, Fabiana
de Carvalho, Fabíola Marques
Barcellos, Fernando Gomes
Prosdocimi, Francisco
May, Gemma
Azevedo Junior, Gilson Martins de
Guimarães, Giselle Moura
Goldman, Gustavo Henrique
Padilha, Itácio Q M
Batista, Jacqueline da Silva
Ferro, Jesus Aparecido
Ribeiro, José M C
Fietto, Juliana Lopes Rangel
Dabbas, Karina Maia
Cerdeira, Louise
Agnez-Lima, Lucymara Fassarella
Brocchi, Marcelo
de Carvalho, Marcos Oliveira
Teixeira, Marcus de Melo
Diniz Maia, Maria de Mascena
Goldman, Maria Helena S
Cruz Schneider, Maria Paula
Felipe, Maria Sueli Soares
Hungria, Mariangela
Nicolás, Marisa Fabiana
Pereira, Maristela
Montes, Martín Alejandro
Cantão, Maurício E
Vincentz, Michel
Rafael, Miriam Silva
Silverman, Neal
Stoco, Patrícia Hermes
Souza, Rangel Celso
Vicentini, Renato
Gazzinelli, Ricardo Tostes
Neves, Rogério de Oliveira
Silva, Rosane
Astolfi-Filho, Spartaco
Maciel, Talles Eduardo Ferreira
Urményi, Turán P
Tadei, Wanderli Pedro
Camargo, Erney Plessmann
de Vasconcelos, Ana Tereza Ribeiro
Abstract: Anopheles darlingi is the principal neotropical malaria vector, responsible for more than a million cases of malaria per year on the American continent. Anopheles darlingi diverged from the African and Asian malaria vectors ∼100 million years ago (mya) and successfully adapted to the New World environment. Here we present an annotated reference A. darlingi genome, sequenced from a wild population of males and females collected in the Brazilian Amazon. A total of 10 481 predicted protein-coding genes were annotated, 72% of which have their closest counterpart in Anopheles gambiae and 21% have highest similarity with other mosquito species. In spite of a long period of divergent evolution, conserved gene synteny was observed between A. darlingi and A. gambiae. More than 10 million single nucleotide polymorphisms and short indels with potential use as genetic markers were identified. Transposable elements correspond to 2.3% of the A. darlingi genome. Genes associated with hematophagy, immunity and insecticide resistance, directly involved in vector-human and vector-parasite interactions, were identified and discussed. This study represents the first effort to sequence the genome of a neotropical malaria vector, and opens a new window through which we can contemplate the evolutionary history of anopheline mosquitoes. It also provides valuable information that may lead to novel strategies to reduce malaria transmission on the South American continent. The A. darlingi genome is accessible at
Subject: Animals
Chromosomes, Insect
Dna Transposable Elements
Evolution, Molecular
Genetic Variation
Genome, Insect
Host-parasite Interactions
Insect Proteins
Insect Vectors
Insecticide Resistance
Molecular Sequence Annotation
Citation: Nucleic Acids Research. v. 41, n. 15, p. 7387-400, 2013-Aug.
Rights: aberto
Identifier DOI: 10.1093/nar/gkt484
Date Issue: 2013
Appears in Collections:Unicamp - Artigos e Outros Documentos

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