Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/200619
Full metadata record
DC FieldValueLanguage
dc.contributor.CRUESPUNIVERSIDADE DE ESTADUAL DE CAMPINASpt_BR
dc.typeArtigo de periódicopt_BR
dc.titleClinical Utility Of Kap-1 Expression In Thyroid Lesions.pt_BR
dc.contributor.authorMartins, Mariana Bonjiornopt_BR
dc.contributor.authorMarcello, Marjory Alanapt_BR
dc.contributor.authorMorari, Elaine Cristinapt_BR
dc.contributor.authorCunha, Lucas Leitept_BR
dc.contributor.authorSoares, Fernando Augustopt_BR
dc.contributor.authorVassallo, Josépt_BR
dc.contributor.authorWard, Laura Sterianpt_BR
unicamp.authorMariana Bonjiorno Martins, Laboratory of Cancer Molecular Genetics, Faculty of Medical Sciences (FCM), University of Campinas (Unicamp), 126, Tessalia Vieira de Camargo St., Barão Geraldo, Campinas, 13083-970, São Paulo, Brazil.pt_BR
unicamp.author.externalMarjory Alana Marcello,pt
unicamp.author.externalElaine Cristina Morari,pt
unicamp.author.externalLucas Leite Cunha,pt
unicamp.author.externalFernando Augusto Soares,pt
unicamp.author.externalJosé Vassallo,pt
unicamp.author.externalLaura Sterian Ward,pt
dc.subjectAdenocarcinoma, Papillarypt_BR
dc.subjectAdolescentpt_BR
dc.subjectAdultpt_BR
dc.subjectAgedpt_BR
dc.subjectAged, 80 And Overpt_BR
dc.subjectCarcinoma, Papillary, Follicularpt_BR
dc.subjectFemalept_BR
dc.subjectHumanspt_BR
dc.subjectHyperplasiapt_BR
dc.subjectMalept_BR
dc.subjectMiddle Agedpt_BR
dc.subjectPrognosispt_BR
dc.subjectRepressor Proteinspt_BR
dc.subjectSurvival Ratept_BR
dc.subjectThyroid Glandpt_BR
dc.subjectThyroid Neoplasmspt_BR
dc.subjectThyroid Nodulept_BR
dc.subjectTumor Markers, Biologicalpt_BR
dc.subjectYoung Adultpt_BR
dc.description.abstractAlthough there are evidences of the involvement of KAP-1 in other tumors, data on differentiated thyroid carcinomas (DTC) are still lacking. We aimed to evaluate KAP-1 clinical utility in the diagnosis and prognosis of DTC. We used both visual immunohistochemistry and a semiquantitative analysis to evaluate KAP-1 expression in 230 thyroid carcinomas and 131 noncancerous thyroid nodules. There were 43 follicular carcinomas (FC) and 187 papillary thyroid carcinomas (PTC), including 130 classic (CPTC), 4 tall cells (TCPTC), and 53 follicular variants (FVPTC). Patients were followed up for 53.8 ± 41 months. They were classified as free-of-disease (142 cases) or poor outcome (25 cases--10 deaths), according to their serum Tg levels and image evidences. KAP-1 was identified in 78 % PTC, 75 % TCPTC, 74 % FC, 72 % FVPTC, 55 % FA, 44 % hyperplasia, and 11 % normal thyroid tissues. A ROC analysis identified malignant nodules with 69 % sensitivity and 75 % specificity, using a cutoff of 73.19. In addition to distinguishing benign from malignant thyroid tissues (p < 0.0001), KAP-1 expression differentiated CPTC from nodular hyperplasia (p < 0.0001), CPTC from FA (p = 0.0028), FVPTC from hyperplasia (p = 0.0039), and FC from hyperplasia (p = 0.0025). Furthermore, KAP-1 was more expressed in larger tumors (>4 cm; p = 0.0038) and in individuals who presented recurrences/metastases (p = 0.0130). We suggest that KAP-1 may help diagnose thyroid nodules, characterize follicular-patterned thyroid lesions, and identify individuals with poor prognosis.en
dc.relation.ispartofEndocrine Pathologypt_BR
dc.relation.ispartofabbreviationEndocr. Pathol.pt_BR
dc.date.issued2013-Junpt_BR
dc.identifier.citationEndocrine Pathology. v. 24, n. 2, p. 77-82, 2013-Jun.pt_BR
dc.language.isoengpt_BR
dc.description.volume24pt_BR
dc.description.firstpage77-82pt_BR
dc.rightsfechadopt_BR
dc.sourcePubMedpt_BR
dc.identifier.issn1559-0097pt_BR
dc.identifier.doi10.1007/s12022-013-9245-zpt_BR
dc.identifier.urlhttp://www.ncbi.nlm.nih.gov/pubmed/23645532pt_BR
dc.date.available2015-11-27T13:31:42Z-
dc.date.accessioned2015-11-27T13:31:42Z-
dc.description.provenanceMade available in DSpace on 2015-11-27T13:31:42Z (GMT). No. of bitstreams: 1 pmed_23645532.pdf: 370985 bytes, checksum: dc9991f8489d114fe3f8bc65a91d3fc0 (MD5) Previous issue date: 2013en
dc.identifier.urihttp://repositorio.unicamp.br/jspui/handle/REPOSIP/200619-
dc.identifier.idPubmed23645532pt_BR
Appears in Collections:Unicamp - Artigos e Outros Documentos

Files in This Item:
File SizeFormat 
pmed_23645532.pdf362.29 kBAdobe PDFView/Open


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.