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Type: Artigo de periódico
Title: Construction And Electrochemical Characterization Of Microelectrodes For Improved Sensitivity In Paper-based Analytical Devices.
Author: Santhiago, Murilo
Wydallis, John B
Kubota, Lauro T
Henry, Charles S
Abstract: This work presents a simple, low cost method for creating microelectrodes for electrochemical paper-based analytical devices (ePADs). The microelectrodes were constructed by backfilling small holes made in polyester sheets using a CO2 laser etching system. To make electrical connections, the working electrodes were combined with silver screen-printed paper in a sandwich type two-electrode configuration. The devices were characterized using linear sweep voltammetry, and the results are in good agreement with theoretical predictions for electrode size and shape. As a proof-of-concept, cysteine was measured using cobalt phthalocyanine as a redox mediator. The rate constant (k(obs)) for the chemical reaction between cysteine and the redox mediator was obtained by chronoamperometry and found to be on the order of 10(5) s(-1) M(-1). Using a microelectrode array, it was possible to reach a limit of detection of 4.8 μM for cysteine. The results show that carbon paste microelectrodes can be easily integrated with paper-based analytical devices.
Subject: Carbon
Organometallic Compounds
Citation: Analytical Chemistry. v. 85, n. 10, p. 5233-9, 2013-May.
Rights: fechado
Identifier DOI: 10.1021/ac400728y
Date Issue: 2013
Appears in Collections:Unicamp - Artigos e Outros Documentos

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