Please use this identifier to cite or link to this item:
Type: Artigo de periódico
Title: A Multimodal Evaluation Of Microstructural White Matter Damage In Spinocerebellar Ataxia Type 3.
Author: Guimarães, Rachel P
D'Abreu, Anelyssa
Yasuda, Clarissa L
França, Marcondes C
Silva, Beatriz H B
Cappabianco, Fabio A M
Bergo, Felipe P G
Lopes-Cendes, Iscia T
Cendes, Fernando
Abstract: Although white matter damage may play a major role in the pathogenesis of spinocerebellar ataxia 3 (SCA3), available data rely exclusively upon macrostructural analyses. In this setting we designed a study to investigate white matter integrity. We evaluated 38 genetically-confirmed SCA3 patients (mean age, 52.76 ± 12.70 years; 21 males) with clinical scales and brain magnetic resonance imaging (MRI) and 38 healthy subjects as a control group (mean age, 48.86 ± 12.07 years, 20 male). All individuals underwent the same protocol for high-resolution T1 and T2 images and diffusion tensor imaging acquisition (32 directions) in a 3-T scanner. We used Tract-Based Spatial Statistics (FSL 4.1.4) to analyze diffusion data and SPM8/DARTEL for voxel-based morphometry of infratentorial structures. T2-relaxometry of cerebellum was performed with in-house-developed software Aftervoxel and Interactive Volume Segmentation (IVS). Patients' mean age at onset was 40.02 ± 11.48 years and mean duration of disease was 9.3 ± 2.7 years. Mean International Cooperative Ataxia Rating Scale (ICARS) and Scale for Assessment and Rating of Ataxia (SARA) scores were 32.08 ± 4.01 and 14.65 ± 7.33, respectively. Voxel-based morphometry demonstrated a volumetric reduction of gray and white matter in cerebellum and brainstem (P <.001). We found reduced fractional anisotropy (P <.05) in the cerebellum and brainstem. There were also areas of increased radial diffusivity (P <.05) in the cerebellum, brainstem, thalamus, frontal lobes, and temporal lobes. In addition, we found decreased T2-relaxation values in the white matter of the right cerebellar hemisphere. Microstructural white matter dysfunction, not previously reported, occurs in the cerebellum and brainstem of SCA3 patients.
Subject: Adult
Brain Mapping
Case-control Studies
Cluster Analysis
Diffusion Tensor Imaging
Imaging, Three-dimensional
Machado-joseph Disease
Middle Aged
Nerve Fibers, Myelinated
Severity Of Illness Index
Machado-joseph Disease
Citation: Movement Disorders : Official Journal Of The Movement Disorder Society. v. 28, n. 8, p. 1125-32, 2013-Jul.
Rights: fechado
Identifier DOI: 10.1002/mds.25451
Date Issue: 2013
Appears in Collections:Unicamp - Artigos e Outros Documentos

Files in This Item:
File SizeFormat 
pmed_23553599.pdf565.1 kBAdobe PDFView/Open

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.