Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/200311
Full metadata record
DC FieldValueLanguage
dc.contributor.CRUESPUNIVERSIDADE DE ESTADUAL DE CAMPINASpt_BR
dc.typeArtigo de periódicopt_BR
dc.titleDisappearance Of Cerebrospinal Fluid Oligoclonal Bands After Natalizumab Treatment Of Multiple Sclerosis Patients.pt_BR
dc.contributor.authorvon Glehn, Felipept_BR
dc.contributor.authorFarias, Alessandro Spt_BR
dc.contributor.authorde Oliveira, Augusto C Penalvapt_BR
dc.contributor.authorDamasceno, Alfredopt_BR
dc.contributor.authorLonghini, Ana Leda Fpt_BR
dc.contributor.authorOliveira, Elaine Cpt_BR
dc.contributor.authorDamasceno, Benito Ppt_BR
dc.contributor.authorSantos, Leonilda M Bpt_BR
dc.contributor.authorBrandão, Carlos Otáviopt_BR
unicamp.authorFelipe von Glehn, Neuroimmunology Unit, Department of Genetics, Evolution and Bioagents, University of Campinas - UNICAMP, Brazil.pt_BR
unicamp.author.externalAlessandro S Farias,pt
unicamp.author.externalAugusto C Penalva de Oliveira,pt
unicamp.author.externalAlfredo Damasceno,pt
unicamp.author.externalAna Leda F Longhini,pt
unicamp.author.externalElaine C Oliveira,pt
unicamp.author.externalBenito P Damasceno,pt
unicamp.author.externalLeonilda M B Santos,pt
unicamp.author.externalCarlos Otávio Brandão,pt
dc.subjectAdultpt_BR
dc.subjectAntibodies, Monoclonal, Humanizedpt_BR
dc.subjectB-lymphocytespt_BR
dc.subjectCd4-positive T-lymphocytespt_BR
dc.subjectFemalept_BR
dc.subjectHumanspt_BR
dc.subjectMalept_BR
dc.subjectMultiple Sclerosis, Relapsing-remittingpt_BR
dc.subjectOligoclonal Bandspt_BR
dc.subjectYoung Adultpt_BR
dc.description.abstractIntrathecal immunoglobulin synthesis in an oligoclonal pattern is the most common immunologic abnormality detected in MS patients. Various treatments, such as immunomodulators and immunosuppressors, have not been found to modify it. Natalizumab hinders migration of encephalitogenic T-cells into the central nervous system (CNS), reducing inflammatory response. Its impact on CSF oligoclonal bands (OCBs) has not been demonstrated. This report describes its effect in four out of six patients with multiple sclerosis after a mean of 10 infusions: the CSF was negative for OCBs at the second lumbar puncture. In conclusion, natalizumab treatment can reduce CSF OCBs to undetectable levels, although the clinical significance of this observation is not yet known.en
dc.relation.ispartofMultiple Sclerosis (houndmills, Basingstoke, England)pt_BR
dc.relation.ispartofabbreviationMult. Scler.pt_BR
dc.date.issued2012-Julpt_BR
dc.identifier.citationMultiple Sclerosis (houndmills, Basingstoke, England). v. 18, n. 7, p. 1038-41, 2012-Jul.pt_BR
dc.language.isoengpt_BR
dc.description.volume18pt_BR
dc.description.firstpage1038-41pt_BR
dc.rightsfechadopt_BR
dc.rights.holderpt_BR
dc.sourcePubMedpt_BR
dc.identifier.issn1477-0970pt_BR
dc.identifier.doi10.1177/1352458511428465pt_BR
dc.identifier.urlhttp://www.ncbi.nlm.nih.gov/pubmed/22041091pt_BR
dc.date.available2015-11-27T13:29:07Z-
dc.date.accessioned2015-11-27T13:29:07Z-
dc.description.provenanceMade available in DSpace on 2015-11-27T13:29:07Z (GMT). No. of bitstreams: 0 Previous issue date: 2012en
dc.identifier.urihttp://repositorio.unicamp.br/jspui/handle/REPOSIP/200311-
dc.identifier.idPubmed22041091pt_BR
Appears in Collections:Unicamp - Artigos e Outros Documentos

Files in This Item:
There are no files associated with this item.


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.