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Type: Artigo de periódico
Title: Suramin Affects Metalloproteinase-9 Activity And Increases β-dystroglycan Levels In The Diaphragm Of The Dystrophin-deficient Mdx Mouse.
Author: Taniguti, Ana Paula Tiemi
Matsumura, Cíntia Yuri
Rodrigues-Simioni, Léa
Santo Neto, Humberto
Marques, Maria Julia
Abstract: In Duchenne muscular dystrophy and in the mdx mouse, muscle fiber degeneration and subsequent fibrosis lead to cardiorespiratory failure. Previously, we demonstrated that the anti-fibrotic agent suramin was effective in decreasing fibrosis in mdx muscles. In this study, we were interested to see whether suramin could affect metalloproteinases (MMP) and improve the functional activity of the mdx diaphragm muscle. Zymography was performed to evaluate MMP-2 and MMP-9 activity. Western blotting was used to analyze the levels of beta-dystroglycan. Muscle function was assessed in hemidiaphragm in vitro preparations. We found that suramin affects metalloproteinase-9 activity and increases beta-dystroglycan. Furthermore, suramin also protects against diaphragm muscle fatigue over time. These results show the potential benefits of suramin in maintaining the structure of the dystrophin-glycoprotein complex.
Subject: Animals
Enzyme Activation
Matrix Metalloproteinase 9
Matrix Metalloproteinase Inhibitors
Mice, Inbred C57bl
Mice, Inbred Mdx
Muscle Fatigue
Muscular Dystrophy, Duchenne
Citation: Muscle & Nerve. v. 46, n. 5, p. 810-3, 2012-Nov.
Rights: fechado
Identifier DOI: 10.1002/mus.23468
Date Issue: 2012
Appears in Collections:Unicamp - Artigos e Outros Documentos

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