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dc.contributor.CRUESPUNIVERSIDADE DE ESTADUAL DE CAMPINASpt_BR
dc.typeArtigo de periódicopt_BR
dc.titleDoxycycline Ameliorates The Dystrophic Phenotype Of Skeletal And Cardiac Muscles In Mdx Mice.pt_BR
dc.contributor.authorPereira, Juliano Alvespt_BR
dc.contributor.authorTaniguti, Ana Paula Tiemipt_BR
dc.contributor.authorMatsumura, Cíntiapt_BR
dc.contributor.authorMarques, Maria Juliapt_BR
dc.contributor.authorNeto, Humberto Santopt_BR
unicamp.authorJuliano Alves Pereira, Departamento de Anatomia, Biologia Celular, Fisiologia e Biofísica, Instituto de Biologia, Universidade Estadual de Campinas, Campinas, São Paulo, 13083-970, Brazil.pt_BR
unicamp.author.externalAna Paula Tiemi Taniguti,pt
unicamp.author.externalCíntia Matsumura,pt
unicamp.author.externalMaria Julia Marques,pt
unicamp.author.externalHumberto Santo Neto,pt
dc.subjectAnimalspt_BR
dc.subjectAnti-bacterial Agentspt_BR
dc.subjectDoxycyclinept_BR
dc.subjectFibrosispt_BR
dc.subjectHeartpt_BR
dc.subjectMicept_BR
dc.subjectMice, Inbred Mdxpt_BR
dc.subjectMuscle Strengthpt_BR
dc.subjectMuscle, Skeletalpt_BR
dc.subjectMuscular Dystrophy, Animalpt_BR
dc.subjectMyocardiumpt_BR
dc.subjectPhenotypept_BR
dc.description.abstractWe examined whether doxycycline, an antibiotic member of the tetracycline family, improves the histopathology and muscle function in mdx mice, the experimental model of DMD. Doxycycline was administered for 36 days (starting on postnatal day 0) and for 9 months (starting at 8 months of age) in drinking water. Histopathological, biochemical (creatine kinase), and functional (forelimb muscle grip strength) parameters were evaluated in limb, diaphragm, and cardiac muscle. Doxycycline significantly minimized the dystrophic phenotype of skeletal and cardiac muscles and improved forelimb muscle strength. The drug protected muscle fibers against myonecrosis and reduced inflammation. Furthermore, it slowed the progression of myocardial fibrosis. This study provides evidence that doxycycline may be a potential therapeutic agent for DMD.en
dc.relation.ispartofMuscle & Nervept_BR
dc.relation.ispartofabbreviationMuscle Nervept_BR
dc.date.issued2012-Seppt_BR
dc.identifier.citationMuscle & Nerve. v. 46, n. 3, p. 400-6, 2012-Sep.pt_BR
dc.language.isoengpt_BR
dc.description.volume46pt_BR
dc.description.firstpage400-6pt_BR
dc.rightsfechadopt_BR
dc.rights.holderCopyright © 2012 Wiley Periodicals, Inc.pt_BR
dc.sourcePubMedpt_BR
dc.identifier.issn1097-4598pt_BR
dc.identifier.doi10.1002/mus.23331pt_BR
dc.identifier.urlhttp://www.ncbi.nlm.nih.gov/pubmed/22907231pt_BR
dc.date.available2015-11-27T13:28:49Z-
dc.date.accessioned2015-11-27T13:28:49Z-
dc.description.provenanceMade available in DSpace on 2015-11-27T13:28:49Z (GMT). No. of bitstreams: 1 pmed_22907231.pdf: 782556 bytes, checksum: 718140b6b91b8e97c93d7e52888a4d36 (MD5) Previous issue date: 2012en
dc.identifier.urihttp://repositorio.unicamp.br/jspui/handle/REPOSIP/200160-
dc.identifier.idPubmed22907231pt_BR
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