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Type: Artigo de periódico
Title: Doxycycline Ameliorates The Dystrophic Phenotype Of Skeletal And Cardiac Muscles In Mdx Mice.
Author: Pereira, Juliano Alves
Taniguti, Ana Paula Tiemi
Matsumura, Cíntia
Marques, Maria Julia
Neto, Humberto Santo
Abstract: We examined whether doxycycline, an antibiotic member of the tetracycline family, improves the histopathology and muscle function in mdx mice, the experimental model of DMD. Doxycycline was administered for 36 days (starting on postnatal day 0) and for 9 months (starting at 8 months of age) in drinking water. Histopathological, biochemical (creatine kinase), and functional (forelimb muscle grip strength) parameters were evaluated in limb, diaphragm, and cardiac muscle. Doxycycline significantly minimized the dystrophic phenotype of skeletal and cardiac muscles and improved forelimb muscle strength. The drug protected muscle fibers against myonecrosis and reduced inflammation. Furthermore, it slowed the progression of myocardial fibrosis. This study provides evidence that doxycycline may be a potential therapeutic agent for DMD.
Subject: Animals
Anti-bacterial Agents
Mice, Inbred Mdx
Muscle Strength
Muscle, Skeletal
Muscular Dystrophy, Animal
Citation: Muscle & Nerve. v. 46, n. 3, p. 400-6, 2012-Sep.
Rights: fechado
Identifier DOI: 10.1002/mus.23331
Date Issue: 2012
Appears in Collections:Unicamp - Artigos e Outros Documentos

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