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dc.contributor.CRUESPUNIVERSIDADE DE ESTADUAL DE CAMPINASpt_BR
dc.typeArtigo de periódicopt_BR
dc.titleComparison Of Metabolic Effects Of Surgical-induced Massive Weight Loss In Patients With Long-term Remission Versus Non-remission Of Type 2 Diabetes.pt_BR
dc.contributor.authorHirsch, Fernanda Filgueirapt_BR
dc.contributor.authorPareja, Jose Carlospt_BR
dc.contributor.authorGeloneze, Sylka Rodovalhopt_BR
dc.contributor.authorChaim, Elintonpt_BR
dc.contributor.authorCazzo, Evertonpt_BR
dc.contributor.authorGeloneze, Brunopt_BR
unicamp.authorFernanda Filgueira Hirsch, LIMED, Laboratory of Investigation on Metabolism and Diabetes, State University of Campinas, UNICAMP, Rua Carlos Chagas 420, 13082-970, Campinas, Brazil. fernandafilgueira@hotmail.compt_BR
unicamp.author.externalJose Carlos Pareja,pt
unicamp.author.externalSylka Rodovalho Geloneze,pt
unicamp.author.externalElinton Chaim,pt
unicamp.author.externalEverton Cazzo,pt
unicamp.author.externalBruno Geloneze,pt
dc.subjectAdiponectinpt_BR
dc.subjectAdolescentpt_BR
dc.subjectAdultpt_BR
dc.subjectArea Under Curvept_BR
dc.subjectBlood Glucosept_BR
dc.subjectBody Mass Indexpt_BR
dc.subjectBrazilpt_BR
dc.subjectC-reactive Proteinpt_BR
dc.subjectDiabetes Mellitus, Type 2pt_BR
dc.subjectFemalept_BR
dc.subjectGastric Bypasspt_BR
dc.subjectGlucagon-like Peptide 1pt_BR
dc.subjectHumanspt_BR
dc.subjectIncretinspt_BR
dc.subjectLeukocytespt_BR
dc.subjectMalept_BR
dc.subjectMiddle Agedpt_BR
dc.subjectObesity, Morbidpt_BR
dc.subjectRemission Inductionpt_BR
dc.subjectRetrospective Studiespt_BR
dc.subjectUric Acidpt_BR
dc.subjectWeight Losspt_BR
dc.subjectYoung Adultpt_BR
dc.description.abstractThe aim of this study was to evaluate the pathophysiological mechanisms underlying the non-remission of type 2 diabetes in Roux-en-Y gastric bypass (RYGB) patients. A group of patients not in remission (NR) was formed (n = 13). A remission group (R) was composed of patients who had undergone normalization of fasting glycemia and A1c, without anti-diabetic drugs and matched for selected baseline characteristics (i.e., duration of disease, previous BMI, final BMI, fat distribution, and age; n = 15). A control group of lean subjects (n = 41) was formed. The NR group had higher uric acid (5.1 vs. 3.9 mg/dL), number of leukocytes (6,866.9 vs. 5,423.6), hs-CRP (0.27 vs. 0.12 mg/dL), MCP-1 (118.4 vs. 64.4 ng/mL), HOMA-IR, and AUC(glucose) but lower adiponectin (9.4 vs. 15.4 ng/mL), leptin (12.7 vs. 20.7 ng/mL), and AUC(GLP-1) in comparison to R group; the NR group also had lower leptin and higher adiponectin, HOMA-IR, AUC(glucose), AUC(C-peptide), AUC(glucagon), and AUC(GLP-1) than controls. The R group had lower MCP-1 and higher adiponectin compared to controls. Insulin sensitivity was significantly lower in the NR group than in the R and control groups. The insulin secretion index values were lower in the NR group than in the R and control groups. This study found greater insulin resistance, lower insulin secretion, persistent adiposopathy and chronic subclinical inflammation, and less robust incretin response in the NR group despite a similar level of weight loss. Persistently altered pathophysiological mechanisms can be related to the lack of remission of type 2 diabetes after RYGB.en
dc.relation.ispartofObesity Surgerypt_BR
dc.relation.ispartofabbreviationObes Surgpt_BR
dc.date.issued2012-Junpt_BR
dc.identifier.citationObesity Surgery. v. 22, n. 6, p. 910-7, 2012-Jun.pt_BR
dc.language.isoengpt_BR
dc.description.volume22pt_BR
dc.description.firstpage910-7pt_BR
dc.rightsfechadopt_BR
dc.sourcePubMedpt_BR
dc.identifier.issn1708-0428pt_BR
dc.identifier.doi10.1007/s11695-012-0589-0pt_BR
dc.identifier.urlhttp://www.ncbi.nlm.nih.gov/pubmed/22246393pt_BR
dc.date.available2015-11-27T13:28:09Z-
dc.date.accessioned2015-11-27T13:28:09Z-
dc.description.provenanceMade available in DSpace on 2015-11-27T13:28:09Z (GMT). No. of bitstreams: 1 pmed_22246393.pdf: 293859 bytes, checksum: 67f25f62f0050b96e9b68d581257069c (MD5) Previous issue date: 2012en
dc.identifier.urihttp://repositorio.unicamp.br/jspui/handle/REPOSIP/199844-
dc.identifier.idPubmed22246393pt_BR
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