Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/199822
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dc.contributor.CRUESPUNIVERSIDADE DE ESTADUAL DE CAMPINASpt_BR
dc.typeArtigo de periódicopt_BR
dc.titleMri-texture Analysis Of Corpus Callosum, Thalamus, Putamen, And Caudate In Machado-joseph Disease.pt_BR
dc.contributor.authorde Oliveira, Márcia Spt_BR
dc.contributor.authorD'Abreu, Anelyssapt_BR
dc.contributor.authorFrança, Marcondes Cpt_BR
dc.contributor.authorLopes-Cendes, Isciapt_BR
dc.contributor.authorCendes, Fernandopt_BR
dc.contributor.authorCastellano, Gabrielapt_BR
unicamp.authorMárcia S de Oliveira, Department of Cosmic Rays and Chronology, Institute of Physics Gleb Wataghin, University of Campinas, São Paulo, Brazil. marciaso@ifi.unicamp.brpt_BR
unicamp.author.externalAnelyssa D'Abreu,pt
unicamp.author.externalMarcondes C França,pt
unicamp.author.externalIscia Lopes-Cendes,pt
unicamp.author.externalFernando Cendes,pt
unicamp.author.externalGabriela Castellano,pt
dc.subjectAdultpt_BR
dc.subjectBrainpt_BR
dc.subjectFemalept_BR
dc.subjectHumanspt_BR
dc.subjectImaging, Three-dimensionalpt_BR
dc.subjectMachado-joseph Diseasept_BR
dc.subjectMalept_BR
dc.subjectNeuronspt_BR
dc.subjectReproducibility Of Resultspt_BR
dc.subjectSensitivity And Specificitypt_BR
dc.description.abstractTexture analysis (TA) is a branch of image processing, which attempts to convey texture information from digital images, such as magnetic resonance images (MRI). Machado-Joseph disease (MJD) affects mainly cerebellum and brainstem, but recent studies have shown that other cerebral structures may also be affected. To investigate subtle structural abnormalities in corpus callosum (CC), thalami, putamen, and caudate nuclei of patients with MJD using TA. Eighteen healthy volunteers and 18 patients with MJD were studied (mean age at disease onset = 34.7 years; disease duration = 9.6 years; mean expanded CAG in the MJD1 gene = 73). A TA approach based on the gray-level cooccurrence matrix was applied to T1-MRI. Regions of interest were manually segmented for each subject, and texture parameters were computed for each of the aforementioned anatomical structures. TA parameters showed differences between the 2 groups for the caudate nuclei, thalami, and putamen. No differences were found for the CC. TA was capable of detecting tissue alterations in MRI of patients with MJD. These alterations were in areas already shown to be affected by histopathological studies. In addition, we confirmed the thalamic involvement in patients with MJD, which had only been demonstrated in volumetric studies.en
dc.relation.ispartofJournal Of Neuroimaging : Official Journal Of The American Society Of Neuroimagingpt_BR
dc.relation.ispartofabbreviationJ Neuroimagingpt_BR
dc.date.issued2012-Janpt_BR
dc.identifier.citationJournal Of Neuroimaging : Official Journal Of The American Society Of Neuroimaging. v. 22, n. 1, p. 46-52, 2012-Jan.pt_BR
dc.language.isoengpt_BR
dc.description.volume22pt_BR
dc.description.firstpage46-52pt_BR
dc.rightsfechadopt_BR
dc.rights.holderCopyright © 2010 by the American Society of Neuroimaging.pt_BR
dc.sourcePubMedpt_BR
dc.identifier.issn1552-6569pt_BR
dc.identifier.doi10.1111/j.1552-6569.2010.00553.xpt_BR
dc.identifier.urlhttp://www.ncbi.nlm.nih.gov/pubmed/21122004pt_BR
dc.date.available2015-11-27T13:28:04Z-
dc.date.accessioned2015-11-27T13:28:04Z-
dc.description.provenanceMade available in DSpace on 2015-11-27T13:28:04Z (GMT). No. of bitstreams: 0 Previous issue date: 2012en
dc.identifier.urihttp://repositorio.unicamp.br/jspui/handle/REPOSIP/199822-
dc.identifier.idPubmed21122004pt_BR
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