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Type: Artigo de periódico
Title: Plasmacytoid Dendritic Cells Are Increased In Cerebrospinal Fluid Of Untreated Patients During Multiple Sclerosis Relapse.
Author: Longhini, Ana Leda F
von Glehn, Felipe
Brandão, Carlos Otávio
de Paula, Rosemeire F O
Pradella, Fernando
Moraes, Adriel S
Farias, Alessandro S
Oliveira, Elaine C
Quispe-Cabanillas, Juan G
Abreu, Cassiana Horta
Damasceno, Alfredo
Damasceno, Benito P
Balashov, Konstantin E
Santos, Leonilda M B
Abstract: The plasmacytoid dendritic cells (pDCs) express a high level of Toll-like receptor 9 (TLR-9), which recognizes viral DNA. Activated via TLR-9, pDCs also secrete large amounts of type I interferon which are involved either in stimulation or down regulation of immune response in multiple sclerosis (MS). In the present study, we determinate pDCs levels by flow cytometry in Cerebrospinal Fluid (CSF) and Peripheral Blood from MS patients in relapsing and in remitting phases of the disease, comparing with other non-inflammatory diseases (OND). We provide evidence that MS patients in relapse without any treatment have a significantly (p < 0.01) higher percentage of pDCs in CSF than do patients in remission or those with OND. No change in the percentage of pDCs was observed in the peripheral blood of any of these patients. The increase of pDCs in central nervous system during relapse may be explained either by a virus infection or a down regulatory process.
Subject: Adult
Cerebrospinal Fluid
Dna, Viral
Dendritic Cells
Middle Aged
Multiple Sclerosis, Relapsing-remitting
Toll-like Receptor 9
Citation: Journal Of Neuroinflammation. v. 8, n. 1, p. 2, 2011.
Rights: aberto
Identifier DOI: 10.1186/1742-2094-8-2
Date Issue: 2011
Appears in Collections:Unicamp - Artigos e Outros Documentos

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