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Type: Artigo de periódico
Title: Prevention Of Muscle Fibrosis And Myonecrosis In Mdx Mice By Suramin, A Tgf-β1 Blocker.
Author: Taniguti, Ana Paula Tiemi
Pertille, Adriana
Matsumura, Cíntia Yuri
Santo Neto, Humberto
Marques, Maria Julia
Abstract: Fibrosis is a pathological feature observed in patients with Duchenne muscular dystrophy (DMD) and in mdx mice, the experimental model of DMD. We evaluated the effect of suramin, a transforming growth factor-beta 1 (TGF-β1) blocker, on fibrosis in mdx mice. mdx mice (6 months old) received suramin for 7 weeks. Suramin- and saline-treated (control) mdx mice performed exercise on a treadmill to worsen disease progression. Immunoblotting showed an increase of TGF-β1 in mdx diaphragm, limb, and cardiac muscles. Suramin decreased creatine kinase in mdx mice and attenuated fibrosis in all muscles studied, except for cardiac muscle. Suramin protected limb muscles against damage and reduced the exercise-induced loss of strength over time. These findings support a role for TGF-β1 in fibrinogenesis and myonecrosis during the later stages of disease in mdx mice. Suramin might be a useful therapeutic alternative for the treatment of dystrophinopathies.
Subject: Animals
Creatine Kinase
Disease Models, Animal
Mice, Inbred C57bl
Mice, Inbred Mdx
Muscle Fibers, Skeletal
Muscle, Skeletal
Physical Conditioning, Animal
Transforming Growth Factor Beta1
Citation: Muscle & Nerve. v. 43, n. 1, p. 82-7, 2011-Jan.
Rights: fechado
Identifier DOI: 10.1002/mus.21869
Date Issue: 2011
Appears in Collections:Unicamp - Artigos e Outros Documentos

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