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dc.contributor.CRUESPUNIVERSIDADE DE ESTADUAL DE CAMPINASpt_BR
dc.typeArtigo de periódicopt_BR
dc.titleOsteopontin, A Chemotactic Protein With Cytokine-like Properties, Is Up-regulated In Muscle Injury Caused By Bothrops Lanceolatus (fer-de-lance) Snake Venom.pt_BR
dc.contributor.authorBarbosa-Souza, Valériapt_BR
dc.contributor.authorContin, Daniel Kisspt_BR
dc.contributor.authorFilho, Waldemar Bonventipt_BR
dc.contributor.authorde Araújo, Albetiza Lôbopt_BR
dc.contributor.authorIrazusta, Silvia Pierrept_BR
dc.contributor.authorda Cruz-Höfling, Maria Alicept_BR
unicamp.authorValéria Barbosa-Souza, Departamento de Farmacologia, Faculdade de Ciências Médicas, Universidade Estadual de Campinas (UNICAMP), CP 6111, 13081-970 Campinas, SP, Brazil.pt_BR
unicamp.author.externalDaniel Kiss Contin,pt
unicamp.author.externalWaldemar Bonventi Filho,pt
unicamp.author.externalAlbetiza Lôbo de Araújo,pt
unicamp.author.externalSilvia Pierre Irazusta,pt
unicamp.author.externalMaria Alice da Cruz-Höfling,pt
dc.subjectAnimalspt_BR
dc.subjectAntigens, Cdpt_BR
dc.subjectAntigens, Differentiation, Myelomonocyticpt_BR
dc.subjectBothropspt_BR
dc.subjectCell Proliferationpt_BR
dc.subjectCrotalid Venomspt_BR
dc.subjectImmunohistochemistrypt_BR
dc.subjectMusclespt_BR
dc.subjectOsteopontinpt_BR
dc.subjectRatspt_BR
dc.subjectRats, Wistarpt_BR
dc.subjectUp-regulationpt_BR
dc.description.abstractOsteopontin (OPN) is a chemotactic, adhesive protein whose receptors include some integrins and matrix proteins known to have role in inflammatory and repair processes. We examined the time course of OPN expression at acute and chronic stages after intramuscular injection of Bothrops lanceolatus venom in rats. Additionally, we examined the expression of CD68 (a marker for phagocytic macrophages) and the myogenic factors, myoD and myogenin. There was a biphasic upregulation of OPN (6-48 h and 3-14 days post-venom), i.e., during acute inflammation and myogenic cell proliferation and differentiation phases. OPN was detected in CD68 + macrophages, fibroblasts, normal and damaged myofibers, myoblasts and myotubes. Myogenin was expressed in the cytoplasm (atypical pattern) and nucleus of myoblasts and myotubes from 18 h to 7 days, after which it was expressed only in nuclei. Macrophage numbers, OPN and myogenin expression were still elevated at 7, 14 and 7 days. At 3 days, when OPN achieved the peak, some clusters of myoblasts were within regions of intense collagen deposition. Fibrosis may represent limitation for repairing processes and may explain the small diameter of regenerated fibers at 21 days post-venom. The expression of OPN in the course of venom-induced damage and regeneration suggests stages-specific mediation role along the whole process.en
dc.relation.ispartofToxicon : Official Journal Of The International Society On Toxinologypt_BR
dc.relation.ispartofabbreviationToxiconpt_BR
dc.date.issued2011-Octpt_BR
dc.identifier.citationToxicon : Official Journal Of The International Society On Toxinology. v. 58, n. 5, p. 398-409, 2011-Oct.pt_BR
dc.language.isoengpt_BR
dc.description.volume58pt_BR
dc.description.firstpage398-409pt_BR
dc.rightsfechadopt_BR
dc.rights.holderCopyright © 2011 Elsevier Ltd. All rights reserved.pt_BR
dc.sourcePubMedpt_BR
dc.identifier.issn1879-3150pt_BR
dc.identifier.doi10.1016/j.toxicon.2011.07.011pt_BR
dc.identifier.urlhttp://www.ncbi.nlm.nih.gov/pubmed/21839764pt_BR
dc.date.available2015-11-27T13:21:46Z-
dc.date.accessioned2015-11-27T13:21:46Z-
dc.description.provenanceMade available in DSpace on 2015-11-27T13:21:46Z (GMT). No. of bitstreams: 1 pmed_21839764.pdf: 4140241 bytes, checksum: a1edfa2e7f610fa5463bb20979f9733d (MD5) Previous issue date: 2011en
dc.identifier.urihttp://repositorio.unicamp.br/jspui/handle/REPOSIP/199584-
dc.identifier.idPubmed21839764pt_BR
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