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Type: Artigo de periódico
Title: Chlorella Vulgaris Restores Bone Marrow Cellularity And Cytokine Production In Lead-exposed Mice.
Author: Queiroz, Mary L S
da Rocha, Michelle C
Torello, Cristiane O
de Souza Queiroz, Julia
Bincoletto, Claudia
Morgano, Marcelo A
Romano, Miriam R
Paredes-Gamero, Edgar J
Barbosa, Christiano M V
Calgarotto, Andrana K
Abstract: Chlorella vulgaris (CV) was examined for its modulating effects on the reduction induced by lead (Pb) on the numbers of marrow hematopoietic stem cells (HSCs) (c-Kit(+)Lin(-)), granulocyte-macrophage progenitors (Gr1(+)Mac1(+)) and total bone marrow cellularity. In mice gavage-treated daily with 50mg/kg dose of CV for 10 days, concomitant to a continuous offering of 1300 ppm lead acetate in drinking water, the treatment with the algae recovered the significantly reduced numbers of these cell populations to control values. As CV may have a myelostimulating effect through the induction of cytokines, we evaluated its modulating effects on the production of IL-1α, TNF-α, IFN-γ, IL-10 and IL-6. Our results demonstrated that lead significantly impairs the production of IFN-γ, IL-1α and TNF-α and increases the production of IL-10 and IL-6 and that these effects are successfully modulated by the CV treatment. The activity of NK cells, reduced in Pb-exposed animals, was raised to levels higher than those of controls in the exposed group treated with CV. Treatment with the algae also stimulated the production of IFN-γ, IL-1α, TNF-α and NK cells activity in normal mice. In addition, zinc bone concentrations, reduced in lead-exposed mice, were partially, but significantly, reversed by the treatment with CV.
Subject: Animals
Bone Marrow Cells
Cell Proliferation
Chlorella Vulgaris
Gene Expression Regulation
Killer Cells, Natural
Mice, Inbred Balb C
Citation: Food And Chemical Toxicology : An International Journal Published For The British Industrial Biological Research Association. v. 49, n. 11, p. 2934-41, 2011-Nov.
Rights: fechado
Identifier DOI: 10.1016/j.fct.2011.06.056
Date Issue: 2011
Appears in Collections:Unicamp - Artigos e Outros Documentos

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