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Type: Artigo de periódico
Title: Growth Hormone Effect On Body Composition In Turner Syndrome.
Author: Baldin, Alexandre Duarte
Fabbri, Tatiana
Siviero-Miachon, Adriana Aparecida
Spinola-Castro, Angela Maria
de Lemos-Marini, Sofia Helena Valente
Baptista, Maria Tereza Matias
D'Souza-Li, Lilia Freire Rodrigues
Maciel-Guerra, Andrea Trevas
Guerra-Junior, Gil
Abstract: This study analyzes the body composition of young adult women with Turner syndrome (TS) either treated or not treated with recombinant human growth hormone (rhGH) and compares them with a group of healthy women. Fifty-two non-treated TS patients (23.0 ± 5.8 years), 30 treated with rhGH (21.5 ± 1.5 years), and 133 healthy young adult women (22.9 ± 3.2 years) were evaluated regarding height (H) and weight, body mass index (BMI), brachial perimeter and tricipital cutaneous fold (fat and lean areas at the arm), sitting height (SRH = sitting height/H × 100), leg length (leg/H), waist and hip circumferences (waist/hip), and bioimpedance (percentages of water, lean mass, and fat mass). Age at start of rhGH therapy varied from 7.8 to 15.1 years (10.0 ± 1.3 years), duration of treatment from 2.8 to 8.2 years (3.7 ± 1.5 years), and the mean dose was 0.42 mg/kg/w (from 0.32 to 0.50 mg/kg/w). Body composition (except height) did not differ between TS groups, but there were differences when compared to the control group: weight and sitting height were lower in TS patients; and BMI, SHR, and leg/H were higher. There was an association between all groups with regards to BMI, waist, SHR, and leg/H, but not in percentage of fat mass. SHR was positively correlated with BMI, waist, hip, and percentage of fat mass. This sample of TS patients (with and without rhGH therapy) did not differ in BMI or body composition. However, there were differences between patients with TS patients and normal healthy women. Regardless of rhGH therapy, TS patients should be monitored, particularly for sitting height, SHR, leg length, leg/H, and waist/hip.
Subject: Adolescent
Body Composition
Body Fat Distribution
Body Mass Index
Case-control Studies
Cross-sectional Studies
Growth Disorders
Human Growth Hormone
Longitudinal Studies
Matched-pair Analysis
Recombinant Proteins
Reference Values
Turner Syndrome
Young Adult
Citation: Endocrine. v. 40, n. 3, p. 486-91, 2011-Dec.
Rights: fechado
Identifier DOI: 10.1007/s12020-011-9504-z
Date Issue: 2011
Appears in Collections:Unicamp - Artigos e Outros Documentos

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