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Type: Artigo de periódico
Title: Plunc Protein Expression In Major Salivary Glands Of Hiv-infected Patients.
Author: da Silva, A A
Bingle, L
Speight, P M
Bingle, C D
Mauad, T
da Silva, L F F
Vargas, P A
Abstract: To analyse and compare the expression of Palate, Lung, and Nasal Epithelium Clone (PLUNC) proteins in salivary glands from patients with and without AIDS (control group) using autopsy material. We analysed the expression of PLUNCs using immunohistochemistry in parotid (n = 45), submandibular (n = 47) and sublingual gland (n = 37) samples of AIDS patients [30 with normal histology, 21 with mycobacteriosis, 14 with cytomegalovirus (CMV) infection, 30 with chronic non-specific sialadenitis, and 30 HIV-negative controls. In situ hybridization (ISH) for SPLUNC 2 in the HIV-negative group was performed.   SPLUNC 1 expression was detected in the mucous acini of submandibular and sublingual glands, and SPLUNC 2 were seen in the serous cells. LPLUNC 1 expression was only positive in the salivary ducts. There was a higher expression of SPLUNC 2 in AIDS patients with CMV infection and mycobacteriosis when compared with all other groups. The intensity of staining for SPLUNC 2 was greater around the lesions than the peripheral ones. ISH for SPLUNC 2 showed perinuclear positivity in the serous cells in all HIV-negative cases.   SPLUNC 1 and LPLUNC 1 proteins were similarly expressed in the salivary glands of AIDS patients and non-HIV patients. CMV infection and mycobacteriosis increase SPLUNC 2 expression in serous cells in the salivary gland of AIDS patients.
Subject: Aids-related Opportunistic Infections
Acquired Immunodeficiency Syndrome
Cytomegalovirus Infections
Hiv Seronegativity
In Situ Hybridization
Middle Aged
Parotid Diseases
Parotid Gland
Salivary Ducts
Salivary Gland Diseases
Salivary Glands
Serous Membrane
Sublingual Gland
Submandibular Gland
Submandibular Gland Diseases
Tuberculosis, Oral
Young Adult
Citation: Oral Diseases. v. 17, n. 3, p. 258-64, 2011-Apr.
Rights: fechado
Identifier DOI: 10.1111/j.1601-0825.2010.01733.x
Date Issue: 2011
Appears in Collections:Unicamp - Artigos e Outros Documentos

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