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Type: Artigo de periódico
Title: Long-term Administration Of Bay 41-2272 Prevents Bladder Dysfunction In Nitric Oxide-deficient Rats.
Author: Mónica, Fabíola Z
Reges, Ricardo
Cohen, David
Silva, Fabio H
De Nucci, Gilberto
D'Ancona, Carlos A L
Antunes, Edson
Abstract: Chronic blockade of nitric oxide (NO) synthesis leads to detrusor smooth muscle overactivity. This study aimed to evaluate the protective effects of BAY 41-2272, a soluble guanlylate cyclase activator, on changes in cystometric parameters in NO-deficient rats. Rats were divided into the following groups: (a) control, (b) DMSO, (c) N(ω)-nitro-L-arginine methyl ester hydrochrolide (L-NAME), (d) BAY 41-2272 alone, and (e) L-NAME + BAY 41-2272. The NO synthase blocker L-NAME (20 mg/rat/day) was giving in the drinking water concomitantly or not with BAY 41-2272 (10 mg/kg/day, given by gavage). Chronic L-NAME treatment markedly increased the mean arterial blood pressure (MABP), and co-treatment with BAY 41-2272 nearly reversed L-NAME-induced rise on MABP. Non-void contractions were significantly increased in L-NAME group (0.90 ± 0.1 number/min) compared with either DMSO or control group (0.49 ± 0.1 number/min), which were prevented by co-treatment with BAY 41-2271 (0.56 ± 025 number/min; P < 0.05). The threshold pressure and peak pressure increased by 70% and 44% after chronic L-NAME treatment, while co-treatment with BAY 41-2272 largely attenuated both of these effects (27% and 22% increase, respectively). The frequency of micturition cycles decreased by about of 50% in L-NAME-treated rats compared with control animals, and co-treatment with BAY 41-2272 normalized this parameter. Our data show that long-term oral administration of BAY 41-2272 counteracts the bladder dysfunction seen in NO-deficient rats, indicating that restoration of the NO-cGMP pathway by this compound may be of beneficial value to treat bladder symptoms.
Subject: Administration, Oral
Analysis Of Variance
Blood Pressure
Disease Models, Animal
Drug Administration Schedule
Enzyme Inhibitors
Guanylate Cyclase
Ng-nitroarginine Methyl Ester
Nitric Oxide
Nitric Oxide Synthase
Rats, Wistar
Receptors, Cytoplasmic And Nuclear
Time Factors
Urinary Bladder
Urinary Bladder, Overactive
Citation: Neurourology And Urodynamics. v. 30, n. 3, p. 456-60, 2011-Mar.
Rights: fechado
Identifier DOI: 10.1002/nau.20992
Date Issue: 2011
Appears in Collections:Unicamp - Artigos e Outros Documentos

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