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Type: Artigo de periódico
Title: Ebv-associated Polymorphic Posttransplant Lymphoproliferative Disorder Presenting As Gingival Ulcers.
Author: León, Jorge Esquiche
Takahama Júnior, Ademar
Vassallo, José
Soares, Fernando Augusto
de Almeida, Oslei Paes
Lopes, Márcio Ajudarte
Abstract: Posttransplant lymphoproliferative disorders (PTLDs) present a wide clinicopathological spectrum, varying from the usual Epstein-Barr virus (EBV)-driven infectious mononucleosis-type polyclonal proliferations to EBV-positive or EBV-negative proliferations indistinguishable from overt lymphomas that occur in immunocompetent individuals. PTLDs characteristically have a predilection for extranodal sites and association with EBV.These disorders are usually B-cell type, although T-cell and rare cases involving both T- and B-cell types have also been described. The initial treatment consists in decreasing the immnosupressive therapy, usually with favorable results. The authors report on a rare case of a 19-year-old girl, with post-renal transplantation EBV-associated polymorphic lymphoproliferative gingival ulcerated lesions. To the best of their knowledge, this is the first case described in the English-language literature of polymorphic PTLD involving both B-cell and T-cell lineages, with an unusual immunoprofile affecting the mouth. The authors warn that this condition could be easily misdiagnosed as malignant lymphoma if not properly recognized.
Citation: International Journal Of Surgical Pathology. v. 19, n. 2, p. 241-6, 2011-Apr.
Rights: fechado
Identifier DOI: 10.1177/1066896909353599
Date Issue: 2011
Appears in Collections:Unicamp - Artigos e Outros Documentos

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