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Type: Artigo de periódico
Title: Female Urethral Carcinoma: Evidences To Origin From Skene's Glands.
Author: Reis, Leonardo Oliveira
Billis, Athanase
Ferreira, Fábio T
Ikari, Lia Y
Stellini, Rafael F
Ferreira, Ubirajara
Abstract: Urethral carcinoma is among the rarest neoplasias of the genitourinary tract and its origin is unclear. Prostate-specific antigen (PSA) is considered an evidence of origin from Skene's glands. We considered the origin from these glands in PSA negative cases. We studied 3 patients with urethral carcinoma surgically treated. The surgical specimens were examined including cytochemical and immunohistochemical stains. The possible origin of the tumors was based on a comparative study of normal Skene's glands from autopsies and noninvolved glands in periurethral tumors. The gross findings and the microscopic examination of 2 adenocarcinomas, including the cytochemical and immunohistochemical studies, favor an origin from Skene's glands. The origin from Skene's glands may be established in PSA negative cases. The establishment of this origin in a higher number of urethral carcinomas may have an impact on diagnostic and treatment strategies in the future.
Subject: Adenocarcinoma
Adenocarcinoma, Clear Cell
Carcinoma, Squamous Cell
Exocrine Glands
Middle Aged
Prostate-specific Antigen
Urethral Neoplasms
Citation: Urologic Oncology. v. 29, n. 2, p. 218-23
Rights: fechado
Identifier DOI: 10.1016/j.urolonc.2009.03.019
Appears in Collections:Unicamp - Artigos e Outros Documentos

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