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Type: Artigo de periódico
Title: Angelica Sinensis Modulates Immunohematopoietic Response And Increases Survival Of Mice Infected With Listeria Monocytogenes.
Author: Queiroz, Mary L S
Torello, Cristiane Okuda
Constantino, Anderson T
Ramos, Aline Lisie
Queiroz, Julia de Souza
Abstract: The effects of a dry extract of the roots of Angelica sinensis (Oliv.) Diels (ASE) on the growth and differentiation of granulocyte-macrophage progenitor cells (CFU-GM) in normal and Listeria monocytogenes-infected mice were studied. Myelosuppression concomitant with increased numbers of spleen CFU-GM was observed in infected mice. Prophylactic administration of ASE (10, 25, and 50 mg/kg) stimulated marrow myelopoiesis in a dose-dependent manner and reduced spleen colony formation to control values. The dose of 50 mg/kg ASE was the optimal biologically active dose in infected mice, and this dose schedule significantly increased survival of mice infected with a lethal dose of L. monocytogenes, with survival rate up to 30%. Investigation of the production of colony-stimulating factors revealed a dose-dependent increased colony-stimulating activity in the serum of infected mice, with higher response produced by the 50 mg/kg dose. Notably, no effects were observed with the 100 mg/kg dose, compared with infected nontreated controls. Further studies to investigate the production of factors such as inteferon-γ and tumor necrosis factor-α demonstrated increased levels of both cytokines in mice infected with L. monocytogenes and treated with 50 mg/kg ASE. We propose that ASE indirectly modulates immune activity and probably disengages Listeria-induced suppression of these responses by inducing a higher reserve of myeloid progenitors in the bone marrow in consequence of biologically active cytokine release (colony-stimulating factors, interferon-γ, and tumor necrosis factor-α).
Subject: Animals
Bone Marrow Cells
Cells, Cultured
Colony-stimulating Factors
Dose-response Relationship, Drug
Drugs, Chinese Herbal
Granulocyte-macrophage Progenitor Cells
Immunologic Factors
Leukocytes, Mononuclear
Listeria Monocytogenes
Mice, Inbred Balb C
Specific Pathogen-free Organisms
Survival Analysis
Tumor Necrosis Factor-alpha
Citation: Journal Of Medicinal Food. v. 13, n. 6, p. 1451-9, 2010-Dec.
Rights: fechado
Identifier DOI: 10.1089/jmf.2009.0108
Date Issue: 2010
Appears in Collections:Unicamp - Artigos e Outros Documentos

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