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Type: Artigo de periódico
Title: Riboflavin And Photoproducts In Mc3t3-e1 Differentiation.
Author: Chaves Neto, Antonio Hernandes
Yano, Claudia Lumy
Paredes-Gamero, Edgar Julian
Machado, Daisy
Justo, Giselle Zenker
Peppelenbosch, Maikel P
Ferreira, Carmen Veríssima
Abstract: Photoderivatives of riboflavin can modulate the proliferation and survival of cancer cells. In this work, we examined the influence of riboflavin and photoderivatives on osteoblast differentiation induced by ascorbic acid and β-glycerophosphate. These compounds decreased the osteoblast proliferation, increased the alkaline phosphatase activity, promoted a reduction in matrix metalloproteinase-2 activity and the decreased in the OPG/RANKL ratio. The effects of flavins on osteoblasts were unrelated to the antioxidant activity of these compounds. The biological activity of osteogenic medium containing riboflavin and its photoderivatives involved the activation of different signaling pathways (AKT, FAK, CaMKII), caspases-3, -8 and -9, and up-regulation of the expression and/or stabilization of osteoblastic transcription factors (Runx2 and β-catenin). These findings suggest a potential use of flavins as adjuvants to improve bone metabolism.
Subject: 3t3 Cells
Cell Differentiation
Cell Proliferation
Signal Transduction
Vitamin B Complex
Citation: Toxicology In Vitro : An International Journal Published In Association With Bibra. v. 24, n. 7, p. 1911-9, 2010-Oct.
Rights: fechado
Identifier DOI: 10.1016/j.tiv.2010.07.026
Date Issue: 2010
Appears in Collections:Unicamp - Artigos e Outros Documentos

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