Modulation Of Hypothalamic Ptp1b In The Tnf-alpha-induced Insulin And Leptin Resistance.

Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/198917

Type:	Artigo de periódico
Title:	Modulation Of Hypothalamic Ptp1b In The Tnf-alpha-induced Insulin And Leptin Resistance.
Author:	Picardi, Paty Karoll Caricilli, Andrea Moro de Abreu, Lélia Lelis Ferreira Carvalheira, José Barreto Campello Velloso, Lício Augusto Saad, Mário José Abdalla
Abstract:	We have associated functional and molecular studies of insulin and leptin to investigate the effect of TNF-alpha on central insulin and leptin signaling in rats pre-treated with PTP1B-ASO. The icv infusion of TNF-alpha-induced an increase in PTP1B protein expression and activity, and attenuated insulin and leptin sensitivity and signaling in the hypothalamus. However, TNF-alpha was able to completely blunt the leptin and insulin effect in rats treated with PTP1B-ASO, suggesting that TNF-alpha does not require PTP1B to fully attenuate the leptin and insulin effects. In addition, our data also show that other mechanisms of insulin and leptin resistance are activated in the hypothalamus by TNF-alpha.
Subject:	Animals Hormones Hypothalamus Immunologic Factors Insulin Insulin Resistance Leptin Male Rats Rats, Wistar Signal Transduction Tumor Necrosis Factor-alpha
Citation:	Febs Letters. v. 584, n. 14, p. 3179-84, 2010-Jul.
Rights:	fechado
Identifier DOI:	10.1016/j.febslet.2010.05.064
Address:	http://www.ncbi.nlm.nih.gov/pubmed/20576518
Date Issue:	2010
Appears in Collections:	Unicamp - Artigos e Outros Documentos

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