Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/198885
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dc.contributor.CRUESPUNIVERSIDADE DE ESTADUAL DE CAMPINASpt_BR
dc.typeArtigo de periódicopt_BR
dc.titleAsymmetrical Hippocampal Connectivity In Mesial Temporal Lobe Epilepsy: Evidence From Resting State Fmri.pt_BR
dc.contributor.authorPereira, Fabrício R Spt_BR
dc.contributor.authorAlessio, Andréapt_BR
dc.contributor.authorSercheli, Maurício Spt_BR
dc.contributor.authorPedro, Tatianept_BR
dc.contributor.authorBilevicius, Elizabethpt_BR
dc.contributor.authorRondina, Jane Mpt_BR
dc.contributor.authorOzelo, Helka F Bpt_BR
dc.contributor.authorCastellano, Gabrielapt_BR
dc.contributor.authorCovolan, Roberto J Mpt_BR
dc.contributor.authorDamasceno, Benito Ppt_BR
dc.contributor.authorCendes, Fernandopt_BR
unicamp.authorFabrício R S Pereira, Neuroimaging Laboratory, Department of Neurology, University of Campinas - UNICAMP, Cidade Universitária, Campinas, SP, Brazil.pt_BR
unicamp.author.externalAndréa Alessio,pt
unicamp.author.externalMaurício S Sercheli,pt
unicamp.author.externalTatiane Pedro,pt
unicamp.author.externalElizabeth Bilevicius,pt
unicamp.author.externalJane M Rondina,pt
unicamp.author.externalHelka F B Ozelo,pt
unicamp.author.externalGabriela Castellano,pt
unicamp.author.externalRoberto J M Covolan,pt
unicamp.author.externalBenito P Damasceno,pt
unicamp.author.externalFernando Cendes,pt
dc.subjectAdultpt_BR
dc.subjectBrain Mappingpt_BR
dc.subjectEpilepsy, Temporal Lobept_BR
dc.subjectFemalept_BR
dc.subjectFunctional Lateralitypt_BR
dc.subjectHippocampuspt_BR
dc.subjectHumanspt_BR
dc.subjectImage Processing, Computer-assistedpt_BR
dc.subjectMagnetic Resonance Imagingpt_BR
dc.subjectMalept_BR
dc.subjectMiddle Agedpt_BR
dc.subjectNerve Netpt_BR
dc.subjectNeuropsychological Testspt_BR
dc.description.abstractMesial temporal lobe epilepsy (MTLE), the most common type of focal epilepsy in adults, is often caused by hippocampal sclerosis (HS). Patients with HS usually present memory dysfunction, which is material-specific according to the hemisphere involved and has been correlated to the degree of HS as measured by postoperative histopathology as well as by the degree of hippocampal atrophy on magnetic resonance imaging (MRI). Verbal memory is mostly affected by left-sided HS, whereas visuo-spatial memory is more affected by right HS. Some of these impairments may be related to abnormalities of the network in which individual hippocampus takes part. Functional connectivity can play an important role to understand how the hippocampi interact with other brain areas. It can be estimated via functional Magnetic Resonance Imaging (fMRI) resting state experiments by evaluating patterns of functional networks. In this study, we investigated the functional connectivity patterns of 9 control subjects, 9 patients with right MTLE and 9 patients with left MTLE. We detected differences in functional connectivity within and between hippocampi in patients with unilateral MTLE associated with ipsilateral HS by resting state fMRI. Functional connectivity resulted to be more impaired ipsilateral to the seizure focus in both patient groups when compared to control subjects. This effect was even more pronounced for the left MTLE group. The findings presented here suggest that left HS causes more reduction of functional connectivity than right HS in subjects with left hemisphere dominance for language.en
dc.relation.ispartofBmc Neurosciencept_BR
dc.relation.ispartofabbreviationBMC Neuroscipt_BR
dc.date.issued2010pt_BR
dc.identifier.citationBmc Neuroscience. v. 11, p. 66, 2010.pt_BR
dc.language.isoengpt_BR
dc.description.volume11pt_BR
dc.description.firstpage66pt_BR
dc.rightsfechadopt_BR
dc.rights.holderpt_BR
dc.sourcePubMedpt_BR
dc.identifier.issn1471-2202pt_BR
dc.identifier.doi10.1186/1471-2202-11-66pt_BR
dc.identifier.urlhttp://www.ncbi.nlm.nih.gov/pubmed/20525202pt_BR
dc.date.available2015-11-27T13:17:55Z-
dc.date.accessioned2015-11-27T13:17:55Z-
dc.description.provenanceMade available in DSpace on 2015-11-27T13:17:55Z (GMT). No. of bitstreams: 1 pmed_20525202.pdf: 3345798 bytes, checksum: c7542af8ecc377a38502f6654edf88ae (MD5) Previous issue date: 2010en
dc.identifier.urihttp://repositorio.unicamp.br/jspui/handle/REPOSIP/198885-
dc.identifier.idPubmed20525202pt_BR
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