Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/198871
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dc.contributor.CRUESPUNIVERSIDADE DE ESTADUAL DE CAMPINASpt_BR
dc.typeArtigo de periódicopt_BR
dc.titlePotent Cardioprotective Effect Of The 4-anilinoquinazoline Derivative Pd153035: Involvement Of Mitochondrial K(atp) Channel Activation.pt_BR
dc.contributor.authorCavalheiro, Renata Apt_BR
dc.contributor.authorMarin, Rodrigo Mpt_BR
dc.contributor.authorRocco, Silvana Apt_BR
dc.contributor.authorCerqueira, Fernanda Mpt_BR
dc.contributor.authorda Silva, Camille C Caldeirapt_BR
dc.contributor.authorRittner, Robertopt_BR
dc.contributor.authorKowaltowski, Alicia Jpt_BR
dc.contributor.authorVercesi, Anibal Ept_BR
dc.contributor.authorFranchini, Kleber Gpt_BR
dc.contributor.authorCastilho, Roger Fpt_BR
unicamp.authorRenata A Cavalheiro, Departamento de Patologia Clínica, Faculdade de Ciências Médicas, Universidade Estadual de Campinas, Campinas, Brazil.pt_BR
unicamp.author.externalRodrigo M Marin,pt
unicamp.author.externalSilvana A Rocco,pt
unicamp.author.externalFernanda M Cerqueira,pt
unicamp.author.externalCamille C Caldeira da Silva,pt
unicamp.author.externalRoberto Rittner,pt
unicamp.author.externalAlicia J Kowaltowski,pt
unicamp.author.externalAnibal E Vercesi,pt
unicamp.author.externalKleber G Franchini,pt
unicamp.author.externalRoger F Castilho,pt
dc.subjectAdenosine Triphosphatept_BR
dc.subjectAnimalspt_BR
dc.subjectBiological Transportpt_BR
dc.subjectCalciumpt_BR
dc.subjectCardiotonic Agentspt_BR
dc.subjectCell Respirationpt_BR
dc.subjectCyanidespt_BR
dc.subjectHeart Function Testspt_BR
dc.subjectIn Vitro Techniquespt_BR
dc.subjectIon Channel Gatingpt_BR
dc.subjectMalept_BR
dc.subjectMicept_BR
dc.subjectMitochondriapt_BR
dc.subjectMyocardial Reperfusion Injurypt_BR
dc.subjectMyocardiumpt_BR
dc.subjectPermeabilitypt_BR
dc.subjectPhosphorylationpt_BR
dc.subjectPotassiumpt_BR
dc.subjectPotassium Channelspt_BR
dc.subjectProto-oncogene Proteins C-aktpt_BR
dc.subjectQuinazolinespt_BR
dc.subjectRatspt_BR
dc.subjectRats, Wistarpt_BR
dc.description.abstractThe aim of the present study was to evaluate the protective effects of the 4-anilinoquinazoline derivative PD153035 on cardiac ischemia/reperfusion and mitochondrial function. Perfused rat hearts and cardiac HL-1 cells were used to determine cardioprotective effects of PD153035. Isolated rat heart mitochondria were studied to uncover mechanisms of cardioprotection. Nanomolar doses of PD153035 strongly protect against heart and cardiomyocyte damage induced by ischemia/reperfusion and cyanide/aglycemia. PD153035 did not alter oxidative phosphorylation, nor directly prevent Ca(2+) induced mitochondrial membrane permeability transition. The protective effect of PD153035 on HL-1 cells was also independent of AKT phosphorylation state. Interestingly, PD153035 activated K(+) transport in isolated mitochondria, in a manner prevented by ATP and 5-hydroxydecanoate, inhibitors of mitochondrial ATP-sensitive K(+) channels (mitoK(ATP)). 5-Hydroxydecanoate also inhibited the cardioprotective effect of PD153035 in cardiac HL-1 cells, demonstrating that this protection is dependent on mitoK(ATP) activation. We conclude that PD153035 is a potent cardioprotective compound and acts in a mechanism involving mitoK(ATP) activation.en
dc.relation.ispartofPlos Onept_BR
dc.relation.ispartofabbreviationPLoS ONEpt_BR
dc.date.issued2010pt_BR
dc.identifier.citationPlos One. v. 5, n. 5, p. e10666, 2010.pt_BR
dc.language.isoengpt_BR
dc.description.volume5pt_BR
dc.description.firstpagee10666pt_BR
dc.rightsabertopt_BR
dc.sourcePubMedpt_BR
dc.identifier.issn1932-6203pt_BR
dc.identifier.doi10.1371/journal.pone.0010666pt_BR
dc.identifier.urlhttp://www.ncbi.nlm.nih.gov/pubmed/20498724pt_BR
dc.date.available2015-11-27T13:17:54Z-
dc.date.accessioned2015-11-27T13:17:54Z-
dc.description.provenanceMade available in DSpace on 2015-11-27T13:17:54Z (GMT). No. of bitstreams: 1 pmed_20498724.pdf: 421834 bytes, checksum: de0fe21a9bdb3b5b1413554a493f4d7c (MD5) Previous issue date: 2010en
dc.identifier.urihttp://repositorio.unicamp.br/jspui/handle/REPOSIP/198871-
dc.identifier.idPubmed20498724pt_BR
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