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Type: Artigo de periódico
Title: Micrornas: A New Paradigm On Molecular Urological Oncology.
Author: Reis, Leonardo Oliveira
Pereira, Tiago Campos
Lopes-Cendes, Iscia
Ferreira, Ubirajara
Abstract: MicroRNAs (miRNA) are a class of naturally occurring, small, noncoding RNAs that function as specific repressors of protein-encoding genes, being pivotal regulators of development and cellular homeostasis. They have been functionally classified as proto-oncogenes or tumor suppressors and are aberrantly expressed in different cancer types. Deregulation of these so-called cancerous miRNAs can figure prominently in tumor initiation and progression. The Human miRNA profile is under development, and it is of concern that there is so little agreement on the miRNAs found in each of the studies. Bioinformatics progress and efficient delivery are essential to overcome barriers to miRNA use in clinical practice.
Subject: Genetic Therapy
Medical Oncology
Rna, Untranslated
Urologic Neoplasms
Citation: Urology. v. 76, n. 3, p. 521-7, 2010-Sep.
Rights: fechado
Identifier DOI: 10.1016/j.urology.2010.03.012
Date Issue: 2010
Appears in Collections:Unicamp - Artigos e Outros Documentos

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