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Type: Artigo de periódico
Title: Family-based Association Study For Bipolar Affective Disorder.
Author: Secolin, Rodrigo
Banzato, Cláudio E M
Oliveira, Maria C M
Bittar, Maria F R
Santos, Marilza L
Dalgalarrondo, Paulo
Lopes-Cendes, Iscia
Abstract: In this study we aimed to evaluate 21 candidate loci for bipolar affective disorder (BPAD) identified earlier in a large genome-wide association study. We evaluated 74 pedigrees with BPAD, with a total of 411 individuals, including 96 patients who fulfilled clinical criteria for BPAD according to Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition classification. Family-based association analysis was performed using the UNPHASED software. We identified a single nucleotide polymorphism (rs9834970) localized on chromosome 3p22.3, showing statistically significant association with BPAD after the Bonferroni correction for multiple comparisons (P(corrected)=0.0025) with an odds ratio=2.64 (95% confidence interval: 1.30-5.35). Single nucleotide polymorphism rs9834970 is located in an intergenic region and is not known to be associated to regulatory genomic sequences.
Subject: Bipolar Disorder
Genetic Association Studies
Genetic Predisposition To Disease
Middle Aged
Polymorphism, Single Nucleotide
Citation: Psychiatric Genetics. v. 20, n. 3, p. 126-9, 2010-Jun.
Rights: fechado
Identifier DOI: 10.1097/YPG.0b013e32833a2050
Date Issue: 2010
Appears in Collections:Unicamp - Artigos e Outros Documentos

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