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Type: Artigo de periódico
Title: Clinical And Genetic Risk Factors For Moderate Hyperbilirubinemia In Brazilian Newborn Infants.
Author: Mezzacappa, M A
Facchini, F P
Pinto, A C
Cassone, A E L
Souza, D S
Bezerra, M A C
Albuquerque, D M
Saad, S T O
Costa, F F
Abstract: To identify clinical and genetic risk factors for moderate hyperbilirubinemia during the first week of life. Using univariate and multivariate multiple regression analyses, the RR for clinical factors, the African variant of glucose-6-phosphate dehydrogenase (G6PD) deficiency (G202A/A376G), and (TA)(n) UGT1A1 polymorphisms were established in a cohort of 608 Brazilian newborn infants. Hyperbilirubinemia was monitored until 134.5 ± 49.8 h of life (IQR, 111.0 to 156.7). The dependent variable was total bilirubinemia (TB) ≥12.9 mg per 100 ml estimated by transcutaneous or plasma bilirubin measurements. The African variant of G6PD deficiency and (TA)(7)/(TA)(7) and (TA)(7)/(TA)(8) polymorphisms present in 6.1 and 12.0% of newborns, respectively, were not risk factors for moderate hyperbilirubinemia. Coexpression of G6DP deficiency and UGT1A1 polymorphisms occurred in 0.49% of the subjects. Independent clinical predictors for TB≥ 12.9 mg per 100 ml were gestational age <38 weeks and reference curve percentiles >P40th. In this study, G6PD deficiency and UGT1A1 gene promoter polymorphisms were not risk factors for moderate hyperbilirubinemia. Genetic factors may vary considerably in importance among different populations.
Subject: Brazil
Cohort Studies
Cross-cultural Comparison
Follow-up Studies
Glucosephosphate Dehydrogenase Deficiency
Heterozygote Detection
Hyperbilirubinemia, Neonatal
Infant, Newborn
Neonatal Screening
Polymorphism, Genetic
Prospective Studies
Risk Factors
Citation: Journal Of Perinatology : Official Journal Of The California Perinatal Association. v. 30, n. 12, p. 819-26, 2010-Dec.
Rights: fechado
Identifier DOI: 10.1038/jp.2010.48
Date Issue: 2010
Appears in Collections:Unicamp - Artigos e Outros Documentos

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