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Type: Artigo de periódico
Title: Leptin And Adiponectin Blood Levels In Women With Premature Ovarian Failure And Age- And Weight-matched Women With Normal Menstrual Cycles.
Author: Benetti-Pinto, Cristina Laguna
Castro, Natália
Grassiotto, Oswaldo da Rocha
Garmes, Heraldo Mendes
Abstract: The aim of this study was to evaluate leptin and adiponectin blood levels in women with premature ovarian failure (POF) and women with a normal menstrual cycle. This was a cross-sectional study involving 60 women divided into two groups: the study group (G1) comprising 30 women with POF not receiving hormone therapy for at least 3 months and the control group (G2) comprising 30 women with a normal menstrual cycle. Both groups were age and body mass index (BMI) matched. Study participants had a mean (+/-SD) age of 34.4 (+/-5.3) and 34.2 (+/-5.6) years and mean BMI (+/-SD) of 24.7 (+/-6.3) and 24.5 (+/-4.6) kg/m in G1 and G2, respectively. Serum leptin levels were significantly lower in G1 compared with G2 (8.8 +/- 12.2 and 12.2 +/- 9.7 ng/mL; P < 0.05). Serum adiponectin levels were similar in both groups. Leptin levels were positively correlated to weight (r = 0.38; P = 0.03) but were not correlated to BMI and age in women with POF (G1); in G2, they were positively correlated to BMI (r = 0.59; P = 0.0006), weight (r = 0.63; P = 0.0006), and age (r = 0.40; P = 0.02). Adiponectin levels did not correlate to weight, BMI, or age in both groups. These results suggest that gonadal function loss may decrease leptin circulating levels, independently from age and BMI. Adiponectin seems not to correlate to hormonal status.
Subject: Adiponectin
Body Mass Index
Body Weight
Case-control Studies
Cross-sectional Studies
Primary Ovarian Insufficiency
Citation: Menopause (new York, N.y.). v. 17, n. 1, p. 174-7
Rights: fechado
Identifier DOI: 10.1097/gme.0b013e3181b00dad
Appears in Collections:Unicamp - Artigos e Outros Documentos

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