Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/198709
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dc.contributor.CRUESPUNIVERSIDADE DE ESTADUAL DE CAMPINASpt_BR
dc.typeArtigo de periódicopt_BR
dc.titleAnti-ulcerogenic Effect Of A Whey Protein Isolate And Collagen Hydrolysates Against Ethanol Ulcerative Lesions On Oral Administration To Rats.pt_BR
dc.contributor.authorCastro, G Apt_BR
dc.contributor.authorCarvalho, J Ept_BR
dc.contributor.authorTinti, S Vpt_BR
dc.contributor.authorPossenti, Apt_BR
dc.contributor.authorSgarbieri, V Cpt_BR
unicamp.authorG A Castro, Departamento de Alimentos e Nutrição, Faculdade de Engenharia de Alimentos, Universidade Estadual de Campinas, Campinas, São Paulo, Brazil. zerogeo@uol.com.brpt_BR
unicamp.author.externalJ E Carvalho,pt
unicamp.author.externalS V Tinti,pt
unicamp.author.externalA Possenti,pt
unicamp.author.externalV C Sgarbieri,pt
dc.subjectAlkylationpt_BR
dc.subjectAnimalspt_BR
dc.subjectAnti-ulcer Agentspt_BR
dc.subjectCarbenoxolonept_BR
dc.subjectCattlept_BR
dc.subjectCollagenpt_BR
dc.subjectDisease Models, Animalpt_BR
dc.subjectDrug Synergismpt_BR
dc.subjectDrug Therapy, Combinationpt_BR
dc.subjectEthanolpt_BR
dc.subjectEthylmaleimidept_BR
dc.subjectGastric Mucosapt_BR
dc.subjectGastrinspt_BR
dc.subjectHydrolysispt_BR
dc.subjectMalept_BR
dc.subjectMilk Proteinspt_BR
dc.subjectMucuspt_BR
dc.subjectRatspt_BR
dc.subjectRats, Wistarpt_BR
dc.subjectStomachpt_BR
dc.subjectStomach Ulcerpt_BR
dc.subjectSulfhydryl Compoundspt_BR
dc.subjectSwinept_BR
dc.description.abstractThe effect of the administration of a whey protein isolate (WPI) and collagen hydrolysates on ethanol-induced ulcerative lesions was studied in rats. WPI and bovine or porcine collagen hydrolysate (BCH and PCH, respectively) were given to rats by gavage. In acute experiments, (single-dose) physiological saline (10 mL/kg of body weight) was used as the negative control, and carbenoxolone (200 mg/kg of body weight) was used as a positive control. Ethanol (1 mL per 250-g rat) was also given by gavage. These treatments reduced the ulcerative lesion index (ULI) in a range of 40-77%, depending on the dosage. Some mixtures of WPI with either PCH or BCH provided results that suggested synergisms between WPI and the collagen hydrolysates. For example, WPI/BCH (in the proportion of 375:375 mg/kg of body weight) decreased ULI by 64%. The mechanism for mucosal protection involved a decrease in plasma gastrin (approximately 40%), a significant increase (50-267%) in mucus production, and a reduction in ULI (percentage) when intragastric administrations were performed after in vivo alkylation by N-ethylmaleimide. Results suggest that gastrin, sulfhydryl substances, and some mechanisms related to mucus production are all involved in gastric ulcer protection against ethanol. The collagen hydrolysates (both PCH and BCH) presented a stronger effect on mucus production; on the other hand, the effect of WPI was also dependent on sulfhydryl compounds, resulting in a more protective effect when the two proteins were administered together.en
dc.relation.ispartofJournal Of Medicinal Foodpt_BR
dc.relation.ispartofabbreviationJ Med Foodpt_BR
dc.date.issued2010-Febpt_BR
dc.identifier.citationJournal Of Medicinal Food. v. 13, n. 1, p. 83-90, 2010-Feb.pt_BR
dc.language.isoengpt_BR
dc.description.volume13pt_BR
dc.description.firstpage83-90pt_BR
dc.rightsfechadopt_BR
dc.sourcePubMedpt_BR
dc.identifier.issn1557-7600pt_BR
dc.identifier.doi10.1089/jmf.2008.0277pt_BR
dc.identifier.urlhttp://www.ncbi.nlm.nih.gov/pubmed/20136440pt_BR
dc.date.available2015-11-27T13:17:32Z-
dc.date.accessioned2015-11-27T13:17:32Z-
dc.description.provenanceMade available in DSpace on 2015-11-27T13:17:32Z (GMT). No. of bitstreams: 0 Previous issue date: 2010en
dc.identifier.urihttp://repositorio.unicamp.br/jspui/handle/REPOSIP/198709-
dc.identifier.idPubmed20136440pt_BR
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