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Type: Artigo de periódico
Title: Brazilian Experience Using High-dose Sequential Chemotherapy Followed By Autologous Hematopoietic Stem Cell Transplantation For Relapsed Or Refractory Hodgkin Lymphoma.
Author: Duarte, Bruno K L
Valente, Isabella
Vigorito, Afonso C
Aranha, Francisco J P
Oliveira-Duarte, Gislaine
Miranda, Eliana C M
Lorand-Metze, Irene
Pagnano, Katia B
Delamain, Marcia
Marques Junior, José F
Brandalise, Silvia R
Nucci, Márcio
De Souza, Carmino A
Abstract: We evaluate the effectiveness and toxicity of high-dose sequential chemotherapy (HDS) as salvage therapy in patients with advanced-stage Hodgkin lymphoma. We performed a retrospective analysis on 77 patients receiving HDS between 1998 and 2006. Patients enrolled were in disease progression or relapsed disease, or did not achieve a complete remission after first-line treatment. HDS consisted of the sequential administration of cyclophosphamide and granulocyte colony-stimulating factor with stem cell harvesting, followed by methotrexate plus vincristine and etoposide. The majority of patients had stage III/IV (64%) and B symptoms (71.4%). Disease status improvement after HDS was observed in 24 of 57 patients (42%) previously in disease progression or relapse. HDS-related deaths occurred in 8 of 77 patients (10.4%). Four patients (5.2%) developed acute myeloid leukemia/myelodysplastic syndrome. Overall, disease-free and progression-free survival was 27%, 57%, and 25%, respectively. Despite the treatment-related mortality, HDS is feasible, with satisfactory response rates, even in patients with poor prognosis.
Subject: Adolescent
Antineoplastic Combined Chemotherapy Protocols
Disease-free Survival
Hematopoietic Stem Cell Transplantation
Hodgkin Disease
Middle Aged
Retrospective Studies
Transplantation, Autologous
Citation: Clinical Lymphoma & Myeloma. v. 9, n. 6, p. 449-54, 2009-Dec.
Rights: aberto
Identifier DOI: 10.3816/CLM.2009.n.088
Date Issue: 2009
Appears in Collections:Unicamp - Artigos e Outros Documentos

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