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dc.contributor.CRUESPUNIVERSIDADE DE ESTADUAL DE CAMPINASpt_BR
dc.typeArtigo de periódicopt_BR
dc.titlePhenylpyrazolone Derivatives Inhibit Gastric Emptying In Rats By A Capsaicin-sensitive Afferent Pathway.pt_BR
dc.contributor.authorVinagre, A Mpt_BR
dc.contributor.authorCollares, E Fpt_BR
unicamp.authorA M Vinagre, Departamento de Pediatria, Universidade Estadual de Campinas, Campinas, SP, Brasil.pt_BR
unicamp.author.externalE F Collares,pt
dc.subjectAfferent Pathwayspt_BR
dc.subjectAmpyronept_BR
dc.subjectAnimalspt_BR
dc.subjectAnimals, Newbornpt_BR
dc.subjectAnti-inflammatory Agents, Non-steroidalpt_BR
dc.subjectAntipyrinept_BR
dc.subjectCapsaicinpt_BR
dc.subjectDipyronept_BR
dc.subjectDose-response Relationship, Drugpt_BR
dc.subjectGastric Emptyingpt_BR
dc.subjectMalept_BR
dc.subjectRatspt_BR
dc.subjectRats, Wistarpt_BR
dc.description.abstractDipyrone (Dp), 4-aminoantipyrine (AA) and antipyrine (At) administered iv and Dp administered icv delay gastric emptying (GE) in rats. The participation of capsaicin (Cps)-sensitive afferent fibers in this phenomenon was evaluated. Male Wistar rats were pretreated sc with Cps (50 mg/kg) or vehicle between the first and second day of life and both groups were submitted to the eye-wiping test. GE was determined in these animals at the age of 8/9 weeks (weight: 200-300 g). Ten minutes before the study, the animals of both groups were treated iv with Dp, AA or At (240 micromol/kg), or saline; or treated icv with Dp (4 micromol/animal) or saline. GE was determined 10 min after treatment by measuring % gastric retention (GR) of saline labeled with phenol red 10 min after orogastric administration. Percent GR (mean +/- SEM, N = 8) in animals pretreated with Cps and treated with Dp, AA or At (35.8 +/- 3.2, 35.4 +/- 2.2, and 35.6 +/- 2%, respectively) did not differ from the GR of saline-treated animals pretreated with vehicle (36.8 +/- 2.8%) and was significantly lower than in animals pretreated with vehicle and treated with the drugs (52.1 +/- 2.8, 66.2 +/- 4, and 55.8 +/- 3%, respectively). The effect of icv administration of Dp (N = 6) was not modified by pretreatment with Cps (63.3 +/- 5.7%) compared to Dp-treated animals pretreated with vehicle (62.3 +/- 2.4%). The results suggest the participation of capsaicin-sensitive afferent fibers in the delayed GE induced by iv administration of Dp, AA and At, but not of icv Dp.en
dc.relation.ispartofBrazilian Journal Of Medical And Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas / Sociedade Brasileira De Biofísica ... [et Al.]pt_BR
dc.relation.ispartofabbreviationBraz. J. Med. Biol. Res.pt_BR
dc.date.issued2009-Novpt_BR
dc.identifier.citationBrazilian Journal Of Medical And Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas / Sociedade Brasileira De Biofísica ... [et Al.]. v. 42, n. 11, p. 1086-9, 2009-Nov.pt_BR
dc.language.isoengpt_BR
dc.description.volume42pt_BR
dc.description.firstpage1086-9pt_BR
dc.rightsabertopt_BR
dc.sourcePubMedpt_BR
dc.identifier.issn1414-431Xpt_BR
dc.identifier.doi10.1590/S0100-879X2009001100014pt_BR
dc.identifier.urlhttp://www.ncbi.nlm.nih.gov/pubmed/19855904pt_BR
dc.date.available2015-11-27T13:15:38Z-
dc.date.accessioned2015-11-27T13:15:38Z-
dc.description.provenanceMade available in DSpace on 2015-11-27T13:15:38Z (GMT). No. of bitstreams: 1 pmed_19855904.pdf: 367179 bytes, checksum: b3f13f6b4cefc8afef6321c0b3081540 (MD5) Previous issue date: 2009en
dc.identifier.urihttp://repositorio.unicamp.br/jspui/handle/REPOSIP/198514-
dc.identifier.idPubmed19855904pt_BR
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