Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/198450
Type: Artigo de periódico
Title: Hemodynamic Effects Of Ropivacaine And Levobupivacaine Intravenous Injection In Swines.
Author: Udelsmann, Artur
Silva, William Adalberto
Moraes, Ana Cristina de
Dreyer, Elisabeth
Abstract: To compare the hemodynamic effects following a toxic dose of either agent after intravenous injection in swines, as might accidentally occur during regional anesthesia in humans. Large White pigs were anesthetized with thiopental, tracheal intubation was performed and mechanical ventilation was instituted. Hemodynamic variables were recorded with invasive pressure monitoring and pulmonary artery catheterization. After a 30-minute resting period, the animals were randomly divided into two groups in a double-blinded fashion and received a bolus intravenous injection of 4 mg.kg-1 of either agent. Hemodynamic results were evaluated at rest and 1, 5, 10, 15, 20 and 30 minutes after intoxication. Hemodynamic repressions of acute intoxication with levobupivacaine were more important and more prolonged than those of ropivacaína. In pigs, levobupivacaine was shown to be more toxic than ropivacaine when the same large doses are injected intravenously.
Subject: Amides
Anesthetics, Intravenous
Anesthetics, Local
Animals
Blood Pressure
Bupivacaine
Chi-square Distribution
Disease Models, Animal
Female
Hemodynamics
Injections, Intravenous
Male
Pulmonary Artery
Random Allocation
Swine
Thiopental
Time Factors
Citation: Acta Cirúrgica Brasileira / Sociedade Brasileira Para Desenvolvimento Pesquisa Em Cirurgia. v. 24, n. 4, p. 296-302
Rights: aberto
Address: http://www.ncbi.nlm.nih.gov/pubmed/19705029
Appears in Collections:Unicamp - Artigos e Outros Documentos

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