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Type: Artigo de periódico
Title: Long-term Therapy With Deflazacort Decreases Myocardial Fibrosis In Mdx Mice.
Author: Marques, Maria Julia
Oggiam, Daniella Silva
Barbin, Isabel Cristina Chagas
Ferretti, Renato
Santo Neto, Humberto
Abstract: We evaluated the effects of long-term administration of deflazacort (DFZ) on the progression of myocardial fibrosis in mdx mice. Mdx mice (6 months old) were treated with DFZ for 15 months. Myocardial fibrosis (MF) was evaluated by histomorphometric methods, and treated and untreated mdx mice of the same age (21 months) were compared. DFZ significantly decreased MF. We conclude that long-term therapy with DFZ is effective in slowing down the progression of fibrosis in the dystrophin-deficient heart.
Subject: Animals
Anti-inflammatory Agents
Mice, Inbred Mdx
Muscular Dystrophy, Animal
Time Factors
Citation: Muscle & Nerve. v. 40, n. 3, p. 466-8, 2009-Sep.
Rights: fechado
Identifier DOI: 10.1002/mus.21341
Date Issue: 2009
Appears in Collections:Unicamp - Artigos e Outros Documentos

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