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Type: Artigo de periódico
Title: Peroxiredoxin I, Platelet-derived Growth Factor A, And Platelet-derived Growth Factor Receptor Alpha Are Overexpressed In Carcinoma Ex Pleomorphic Adenoma: Association With Malignant Transformation.
Author: Demasi, Ana Paula Dias
Furuse, Cristiane
Soares, Andresa B
Altemani, Albina
Araújo, Vera C
Abstract: Carcinoma ex pleomorphic adenoma is a rare salivary gland malignancy. It constitutes an important model for the study of carcinogenesis, as it can display the tumor in different stages of progression, from benign pleomorphic adenoma to frankly invasive carcinoma. Growth signaling pathways undergo continuous activation in human tumors, commonly as a consequence of the overexpression of ligands and receptors such as platelet-derived growth factor and platelet-derived growth factor receptor. Hydrogen peroxide is produced after platelet-derived growth factor receptor activation, and it is essential for the sequential phosphorylation cascade that drives cell proliferation and migration. By their ability to degrade hydrogen peroxide, peroxiredoxins are involved in growth factor signaling regulation and in the oxidative stress response. To verify the potential association of peroxiredoxin I, platelet-derived growth factor-A, and platelet-derived growth factor receptor-alpha with carcinoma ex pleomorphic adenoma progression, we investigated the expression of these molecules in carcinoma ex pleomorphic adenoma showing different degrees of invasion. The peroxiredoxin I, platelet-derived growth factor-A, and platelet-derived growth factor receptor-alpha proteins were present in remnant pleomorphic adenoma to only a small extent, but, collectively, they were highly expressed as soon as the malignant phenotype was achieved and remained at elevated concentrations during progression to the advanced stages of carcinoma ex pleomorphic adenoma. In addition, their locations overlapped significantly, strengthening their connection to this growth-signaling pathway. Our results indicate that carcinoma ex pleomorphic adenoma cells acquire at least 2 significant advantages relative to their normal counterparts: resistance to oxidative stress-induced apoptosis, conferred by high peroxiredoxin I concentrations, and sustained growth, reflecting platelet-derived growth factor-A and platelet-derived growth factor receptor-alpha overexpression.
Subject: Adenocarcinoma
Adenoma, Pleomorphic
Cell Transformation, Neoplastic
Middle Aged
Neoplasms, Second Primary
Receptor, Platelet-derived Growth Factor Alpha
Salivary Gland Neoplasms
Salivary Glands
Signal Transduction
Tumor Markers, Biological
Citation: Human Pathology. v. 40, n. 3, p. 390-7, 2009-Mar.
Rights: fechado
Identifier DOI: 10.1016/j.humpath.2008.06.030
Date Issue: 2009
Appears in Collections:Unicamp - Artigos e Outros Documentos

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