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Type: Artigo de periódico
Title: Nad(p)h- And Superoxide-dependent Nitric Oxide Degradation By Rat Liver Mitochondria.
Author: Oliveira, Halley Caixeta
Saviani, Elzira Elisabeth
Salgado, Ione
Abstract: Mitochondria consume nitric oxide (NO) mainly through reaction with superoxide anion (O(2)(-)). Here, we analyzed the O(2)(-) sources for NO degradation by isolated rat liver mitochondria. Electron leakage from complex III and reverse electron transport to complex I accounted for O(2)(-)-dependent NO degradation by mitochondria in the presence of a protonmotive force. Mitochondria incubated with NAD(P)H also presented intense O(2)(-) generation and NO degradation rates that were insensitive to respiratory inhibitors and abolished after proteinase treatment. These results suggest that an outer membrane-localized NAD(P)H oxidase activity, in addition to the electron leakage from the respiratory chain, promotes O(2)(-)-dependent NO degradation in rat liver mitochondria.
Subject: Animals
Mitochondria, Liver
Nadph Oxidase
Nitric Oxide
Rats, Wistar
Citation: Febs Letters. v. 583, n. 13, p. 2276-80, 2009-Jul.
Rights: fechado
Identifier DOI: 10.1016/j.febslet.2009.06.012
Date Issue: 2009
Appears in Collections:Unicamp - Artigos e Outros Documentos

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