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dc.contributor.CRUESPUNIVERSIDADE DE ESTADUAL DE CAMPINASpt_BR
dc.typeArtigo de periódicopt_BR
dc.titleRole Of The Vitamin C In Diethylnitrosamine-induced Esophageal Cancer In Wistar Rats.pt_BR
dc.contributor.authorRamos, Almino Cardosopt_BR
dc.contributor.authorAraujo, Marina Rachelpt_BR
dc.contributor.authorLopes, Luiz Robertopt_BR
dc.contributor.authorAndreollo, Nelson Adamipt_BR
unicamp.authorAlmino Cardoso Ramos, School of Medical Sciences, UNICAMP, Campinas, SP, Brazil.pt_BR
unicamp.author.externalMarina Rachel Araujo,pt
unicamp.author.externalLuiz Roberto Lopes,pt
unicamp.author.externalNelson Adami Andreollo,pt
dc.subjectAnimalspt_BR
dc.subjectAnticarcinogenic Agentspt_BR
dc.subjectAscorbic Acidpt_BR
dc.subjectCarcinogenspt_BR
dc.subjectDiethylnitrosaminept_BR
dc.subjectEsophageal Neoplasmspt_BR
dc.subjectLiver Neoplasms, Experimentalpt_BR
dc.subjectMalept_BR
dc.subjectRatspt_BR
dc.subjectRats, Wistarpt_BR
dc.subjectStatistics, Nonparametricpt_BR
dc.description.abstractTo evaluate the inhibitory effect of vitamin C on the experimental esophageal carcinogenesis induced by diethylnitrosamine (NDEA). Sixty Wistar male rats aged three months, with mean weight of 210 g were employed in the study and were divided into four different groups according to the drinking drugs: group I--controls: only water, seven days a week; group II--only vitamin C, seven days a week; group III--NDEA, three days a week and water during the other four days; group IV--NDEA, three days a week and vitamin C during the other four days; group V--NDEA together with vitamin C three days a week, and only water during the other four days and group VI--NDEA together with vitamin C three days a week and vitamin C during the other four days. The dosages of NDEA were: --10 mg./Kg/day and vitamin C--200 mg/animal/day, dissolved in drinking water. The animals were observed during 180 days and after that each one was sacrificed and its esophagus and the stomach were removed together and macro and microscopically analyzed to identify any tumors. The largest number of tumors was observed in the group III: 48 macroscopic lesions (4.8 lesions per animal) and 23 microscopic lesions (2.3 lesions per animal). The groups that received vitamin C (groups IV, V and VI) showed smaller number of tumors: group V--0.5 macroscopic lesions and 0.3 microscopic lesions per animal and group VI--0.1 macroscopic lesions and 0.1 microscopic lesions per animal. The incidence of tumors in the groups V and VI showed statistical significance (p<0.05), when compared to the other groups. The vitamin C administered together with diethylnitrosamine showed an inhibitory effect on the experimental esophageal carcinogenesis in Wistar rats.en
dc.relation.ispartofActa Cirúrgica Brasileira / Sociedade Brasileira Para Desenvolvimento Pesquisa Em Cirurgiapt_BR
dc.relation.ispartofabbreviationActa Cir Braspt_BR
dc.identifier.citationActa Cirúrgica Brasileira / Sociedade Brasileira Para Desenvolvimento Pesquisa Em Cirurgia. v. 24, n. 3, p. 183-8pt_BR
dc.language.isoengpt_BR
dc.description.volume24pt_BR
dc.description.firstpage183-8pt_BR
dc.rightsabertopt_BR
dc.sourcePubMedpt_BR
dc.identifier.issn1678-2674pt_BR
dc.identifier.urlhttp://www.ncbi.nlm.nih.gov/pubmed/19503999pt_BR
dc.date.available2015-11-27T13:15:18Z-
dc.date.accessioned2015-11-27T13:15:18Z-
dc.description.provenanceMade available in DSpace on 2015-11-27T13:15:18Z (GMT). No. of bitstreams: 1 pmed_19503999.pdf: 170171 bytes, checksum: a9f8b2618a76a393d3f68a3cc1d94406 (MD5) Previous issue date: nullen
dc.identifier.urihttp://repositorio.unicamp.br/jspui/handle/REPOSIP/198355-
dc.identifier.idPubmed19503999pt_BR
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