Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/198350
Type: Artigo
Title: Identification of a bioactive compound isolated from brazilian propolis type 6
Author: Castro, Myrella Lessio
do Nascimento, Andréa Mendes
Ikegaki, Masaharu
Costa-Neto, Cláudio M.
Alencar, Severino M.
Rosalen, Pedro L.
Abstract: A prenylated benzophenone, hyperibone A, was isolated from the hexane fraction of Brazilian propolis type 6. Its structure was determined by spectral analysis including 2D NMR. This compound exhibited cytotoxic activity against HeLa tumor cells (IC(50)=0.1756microM), strong antimicrobial activity (MIC range-0.73-6.6microg/mL; MBC range-2.92-106microg/mL) against Streptococcus mutans, Streptococcus sobrinus, Streptococcus oralis, Staphylococcus aureus, and Actinomyces naeslundii, and the results of its cytotoxic and antimicrobial activities were considered good.
A prenylated benzophenone, hyperibone A, was isolated from the hexane fraction of Brazilian propolis type 6. Its structure was determined by spectral analysis including 2D NMR. This compound exhibited cytotoxic activity against HeLa tumor cells (IC(50)=0.1756microM), strong antimicrobial activity (MIC range-0.73-6.6microg/mL; MBC range-2.92-106microg/mL) against Streptococcus mutans, Streptococcus sobrinus, Streptococcus oralis, Staphylococcus aureus, and Actinomyces naeslundii, and the results of its cytotoxic and antimicrobial activities were considered good
Subject: Própolis
Atividade biológica
Country: Inglaterra
Editor: Elsevier Pergamon
Citation: Bioorganic & Medicinal Chemistry. v. 17, n. 14, p. 5332-5, 2009-Jul.
Rights: fechado
Identifier DOI: 10.1016/j.bmc.2009.04.066
Address: https://www.sciencedirect.com/science/article/pii/S0968089609004350?via%3Dihub
Date Issue: 2009
Appears in Collections:FOP - Artigos e Outros Documentos

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