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Type: Artigo de periódico
Title: Epidemiological And Molecular Mechanisms Aspects Linking Obesity And Cancer.
Author: Osório-Costa, Felipe
Rocha, Guilherme Z
Dias, Marília M
Carvalheira, José B C
Abstract: About 25% of cancer cases globally are due to excess weight and a sedentary lifestyle. These results are alarming, as the world knows a pandemic of obesity and, in consequence, insulin resistance. Obesity may increase risk for various cancers by several mechanisms, including increasing sex and metabolic hormones, and inflammation. Here, we present a review of epidemiological and molecular evidences linking obesity and cancer--particularly colorectal, post-menopausal breast, endometrial, pancreatic, high grade prostate, hepatocellular, gallbladder, kidney and esophageal adenocarcinoma. The expected striking increase in the incidence of cancer in the near future related to obesity turns the knowledge of this field of great impact as it is needed to the development of strategies to prevent and treat this disease.
Subject: Adipose Tissue
Gonadal Steroid Hormones
Insulin Resistance
Citation: Arquivos Brasileiros De Endocrinologia E Metabologia. v. 53, n. 2, p. 213-26, 2009-Mar.
Rights: aberto
Date Issue: 2009
Appears in Collections:Unicamp - Artigos e Outros Documentos

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