Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/198284
Type: Artigo de periódico
Title: Bioactivation Of Alumina By Surface Modification: A Possibility For Improving The Applicability Of Alumina In Bone And Oral Repair.
Author: Bertazzo, S
Zambuzzi, W F
da Silva, H A
Ferreira, C V
Bertran, C A
Abstract: In regenerative medicine, surface engineering of bioinert synthetic materials is often required in order to introduce bioactive species that can promote cell adhesion, proliferation, viability and enhanced ECM-secretion functions. The aim of this work is to study cell interaction with alumina-modified surfaces. In this work, chemical properties of alumina surface were changed by a reaction at the surface of alumina with low molecular weight dicarboxylic acid, which produced carboxyl groups. These carboxyl groups were able to complex with Ca2+ on the surface, forming sites of precipitation for calcium phosphates that make alumina biocompatible, as indicated by cell culture of pre-osteoblasts (MC3T3-E1 cell line). The procedure presented in this work shows that the insertion of specific functional groups on the surface of alumina increases cell interaction with the surface of alumina. This knowledge can be important in oral science and orthopedics, for the construction of prosthesis.
Subject: Aluminum
Animals
Biocompatible Materials
Calcium
Carbon Dioxide
Cell Adhesion
Cell Differentiation
Cell Survival
Fibroblasts
Mice
Osteoblasts
Surface Properties
Citation: Clinical Oral Implants Research. v. 20, n. 3, p. 288-93, 2009-Mar.
Rights: fechado
Identifier DOI: 10.1111/j.1600-0501.2008.01642.x
Address: http://www.ncbi.nlm.nih.gov/pubmed/19397640
Date Issue: 2009
Appears in Collections:Unicamp - Artigos e Outros Documentos

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