Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/198229
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dc.contributor.CRUESPUNIVERSIDADE DE ESTADUAL DE CAMPINASpt_BR
dc.typeArtigo de periódicopt_BR
dc.titlePrevalence Of Thyroid Dysfunction In Systemic Lupus Erythematosus.pt_BR
dc.contributor.authorAppenzeller, Simonept_BR
dc.contributor.authorPallone, Ana Tpt_BR
dc.contributor.authorNatalin, Ricardo Apt_BR
dc.contributor.authorCostallat, Lilian T Lpt_BR
unicamp.authorSimone Appenzeller, Department of Internal Medicine, FCM, Rheumatology Unit-Faculty of Medical Sciences-State University of Campinas (UNICAMP), Sao Paulo, Brazil. appenzellersimone@yahoo.compt_BR
unicamp.author.externalAna T Pallone,pt
unicamp.author.externalRicardo A Natalin,pt
unicamp.author.externalLilian T L Costallat,pt
dc.subjectAdolescentpt_BR
dc.subjectAdultpt_BR
dc.subjectBrazilpt_BR
dc.subjectChildpt_BR
dc.subjectFemalept_BR
dc.subjectGraves Diseasept_BR
dc.subjectHumanspt_BR
dc.subjectLupus Erythematosus, Systemicpt_BR
dc.subjectMalept_BR
dc.subjectMiddle Agedpt_BR
dc.subjectPrevalencept_BR
dc.subjectRetrospective Studiespt_BR
dc.subjectSjogren's Syndromept_BR
dc.subjectThyroiditis, Autoimmunept_BR
dc.subjectYoung Adultpt_BR
dc.description.abstractTo report the prevalence and clinical relevance of autoimmune thyroid disease and thyroid antibodies in 524 patients with SLE. The medical charts of SLE patients followed in our rheumatology unit were reviewed to determine the prevalence and clinical associations of autoimmune thyroid disease. These findings were compared with the prevalence of autoimmune thyroid disease in 50 female adults. Chi(2) tests and Fisher exact tests were used in the comparison of the groups for the categorical variables and Mann-Whitney U test for the continuous variables. Spearman rank correlation was used to identify an association between thyroid symptoms and disease activity. Symptomatic autoimmune thyroid disease was observed in 32 of 524 (6.1%) SLE patients and in 1 of 50 controls (P > 0.05), predominantly hypothyroidism (28 SLE patients vs. in 1 control). Subclinical thyroid disease was identified in 60 (11.5%) and positive thyroid autoantibodies in the absence of thyroid disease in 89 of 524 (17%) SLE patients. Thyroid autoantibodies preceded the occurrence of clinical autoimmune thyroid disease in 70% of SLE patients. Sjögren syndrome (P = 0.001) and positive rheumatoid factor (P = 0.04) were more frequently observed in SLE patients with autoimmune thyroid disease when compared with SLE patients without autoimmune thyroid disease. Disease activity of the SLE was correlated with the presence of symptoms of hyperthyroidism (r = 0.4; P = 0.004). Our patients with SLE had a high prevalence of symptomatic and significantly more subclinical hypothyroidism and positive thyroid autoantibodies. Thyroid autoantibodies may precede the appearance of clinical autoimmune disease. Sjögren syndrome and positive rheumatoid factors were more frequently observed in SLE patients with autoimmune thyroid disease. We believe that, since symptoms of SLE and thyroid disease can be similar, that SLE patients should routinely been investigated for autoimmune thyroid disease.en
dc.relation.ispartofJournal Of Clinical Rheumatology : Practical Reports On Rheumatic & Musculoskeletal Diseasespt_BR
dc.relation.ispartofabbreviationJ Clin Rheumatolpt_BR
dc.date.issued2009-Aprpt_BR
dc.identifier.citationJournal Of Clinical Rheumatology : Practical Reports On Rheumatic & Musculoskeletal Diseases. v. 15, n. 3, p. 117-9, 2009-Apr.pt_BR
dc.language.isoengpt_BR
dc.description.volume15pt_BR
dc.description.firstpage117-9pt_BR
dc.rightsfechadopt_BR
dc.sourcePubMedpt_BR
dc.identifier.issn1536-7355pt_BR
dc.identifier.doi10.1097/RHU.0b013e31819dbe4cpt_BR
dc.identifier.urlhttp://www.ncbi.nlm.nih.gov/pubmed/19300286pt_BR
dc.date.available2015-11-27T13:15:00Z-
dc.date.accessioned2015-11-27T13:15:00Z-
dc.description.provenanceMade available in DSpace on 2015-11-27T13:15:00Z (GMT). No. of bitstreams: 0 Previous issue date: 2009en
dc.identifier.urihttp://repositorio.unicamp.br/jspui/handle/REPOSIP/198229-
dc.identifier.idPubmed19300286pt_BR
Appears in Collections:Unicamp - Artigos e Outros Documentos

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