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Type: Artigo de periódico
Title: Interferon-beta Modifies The Peripheral Blood Cell Cytokine Secretion In Patients With Multiple Sclerosis.
Author: Mirandola, Sandra R
Hallal, Dannie E M
Farias, Alessandro S
Oliveira, Elaine C
Brandão, Carlos O
Ruocco, Heloisa H
Damasceno, Benito P
Santos, Leonilda M B
Abstract: Immunotherapy with Interferon-beta (IFNbeta) results in remarkably beneficial effects in patients with relapsing-remitting multiple sclerosis (MS), although the mechanisms by which it exerts these beneficial effects remain poorly understood. An investigation was made of the effects of IFNbeta on pro-inflammatory and anti-inflammatory cytokine production in peripheral blood cells in MS patients, both untreated and those undergoing immunotherapy, as well as in healthy controls. Results show a significant increase in the production of pro-inflammatory cytokines such as TNFalpha, IFNgamma and IL-12 in the plasma and in the supernatant of leukocyte cultures from MS patients with the untreated disease; IFNbeta administration significantly reduced the levels of TNFalpha and IFNgamma, with no changes in the level of IL-12. The Interferon-beta therapy also led to a significant increase in the production of IL-10, as well as a slight increase in that of TGFbeta. The reduction in pro-inflammatory cytokine production in the treated MS patient group, accompanied by a simultaneous increase in the production of anti-inflammatory cytokines and the reduction of relapse rates suggests that the beneficial effects of IFNbeta immunotherapy result, at least in part, from the modulation of cytokine patterns.
Subject: Adolescent
Middle Aged
Multiple Sclerosis
Tumor Necrosis Factor-alpha
Citation: International Immunopharmacology. v. 9, n. 7-8, p. 824-30, 2009-Jul.
Rights: fechado
Identifier DOI: 10.1016/j.intimp.2009.03.004
Date Issue: 2009
Appears in Collections:Unicamp - Artigos e Outros Documentos

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