Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/198187
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dc.contributor.CRUESPUNIVERSIDADE DE ESTADUAL DE CAMPINASpt_BR
dc.typeArtigo de periódicopt_BR
dc.titleAxonal Dysfunction In The Deep White Matter In Machado-joseph Disease.pt_BR
dc.contributor.authorD'Abreu, Anelyssapt_BR
dc.contributor.authorFrança, Marcondespt_BR
dc.contributor.authorAppenzeller, Simonept_BR
dc.contributor.authorLopes-Cendes, Isciapt_BR
dc.contributor.authorCendes, Fernandopt_BR
unicamp.authorAnelyssa D'Abreu, Neuroimaging Laboratory, Universidade Estadual de Campinas-UNICAMP, Campinas São Paulo, Brazil.pt_BR
unicamp.author.externalMarcondes França,pt
unicamp.author.externalSimone Appenzeller,pt
unicamp.author.externalIscia Lopes-Cendes,pt
unicamp.author.externalFernando Cendes,pt
dc.subjectAdultpt_BR
dc.subjectAgedpt_BR
dc.subjectAspartic Acidpt_BR
dc.subjectCase-control Studiespt_BR
dc.subjectCholinept_BR
dc.subjectCreatinept_BR
dc.subjectFemalept_BR
dc.subjectHumanspt_BR
dc.subjectMachado-joseph Diseasept_BR
dc.subjectMagnetic Resonance Imagingpt_BR
dc.subjectMagnetic Resonance Spectroscopypt_BR
dc.subjectMalept_BR
dc.subjectMiddle Agedpt_BR
dc.subjectNerve Fibers, Myelinatedpt_BR
dc.subjectPhosphocreatinept_BR
dc.description.abstractWe evaluated spectroscopy findings at the deep white matter in Machado-Joseph disease (MJD). We obtained brain MRI and single-voxel proton MR spectroscopy (MRS) over the superior-posterior region of the left hemisphere at the level of the corpus callosum in 40 patients (44.6 +/- 2.3 years-old) and 27 controls (31.4 +/- 3.6 years). Four patients were excluded due to poor quality spectra. We observed a decrease in signal intensity of N-acetylaspartate relative to creatine-phosphocreatine signal (NAA/Cr) in MJD compared to control [1.63 +/- 0.41 (1.15-2.76) versus 1.97 +/- .51 (1.50-2.92); U test = 219.0; P < .001]. No statistical difference was observed in choline-containing compounds relative to creatine (Cho/Cr). There was no significant correlation between NAA/Cr and clinical and genetic variables. Due to the younger age of the control group, we performed a secondary analysis in a subgroup of 15 MJD patients matched by age to 15 controls. Matching was performed blindly to MRS results and subject identification, except for age and sex. A statistically significant difference was observed in NAA/Cr ratios (U test = 44.0; P= .004), as well as Cho/Cr levels (U test = 53.0; P= .014). We conclude that the metabolic abnormalities observed in the deep white matter in MJD suggest extensive neuronal and axonal dysfunction in these patients.en
dc.relation.ispartofJournal Of Neuroimaging : Official Journal Of The American Society Of Neuroimagingpt_BR
dc.relation.ispartofabbreviationJ Neuroimagingpt_BR
dc.date.issued2009-Janpt_BR
dc.identifier.citationJournal Of Neuroimaging : Official Journal Of The American Society Of Neuroimaging. v. 19, n. 1, p. 9-12, 2009-Jan.pt_BR
dc.language.isoengpt_BR
dc.description.volume19pt_BR
dc.description.firstpage9-12pt_BR
dc.rightsfechadopt_BR
dc.sourcePubMedpt_BR
dc.identifier.issn1552-6569pt_BR
dc.identifier.doi10.1111/j.1552-6569.2008.00260.xpt_BR
dc.identifier.urlhttp://www.ncbi.nlm.nih.gov/pubmed/18482370pt_BR
dc.date.available2015-11-27T13:14:53Z-
dc.date.accessioned2015-11-27T13:14:53Z-
dc.description.provenanceMade available in DSpace on 2015-11-27T13:14:53Z (GMT). No. of bitstreams: 1 pmed_18482370.pdf: 119593 bytes, checksum: 87ff867905a4e2529a6b94260c287456 (MD5) Previous issue date: 2009en
dc.identifier.urihttp://repositorio.unicamp.br/jspui/handle/REPOSIP/198187-
dc.identifier.idPubmed18482370pt_BR
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