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Type: Artigo de periódico
Title: Exercise Training Reduces Pulmonary Ischaemia-reperfusion-induced Inflammatory Responses.
Author: Mussi, R K
Camargo, E A
Ferreira, T
De Moraes, C
Delbin, M A
Toro, I F C
Brancher, S
Landucci, E C T
Zanesco, A
Antunes, E
Abstract: Physical exercise reduces the deleterious effects of cardiovascular and inflammatory disorders. The purpose of the present study was to evaluate the beneficial effects of physical training on the inflammatory responses following lung ischaemia-reperfusion (IR) in rats. Male Wistar rats were divided into sham-operated animals and sedentary and trained animals submitted to lung IR. The run training programme consisted of 5 sessions.week(-1), each lasting 60, at 66% of maximal oxygen consumption for 8 weeks. The left pulmonary artery, bronchus and pulmonary vein were occluded for 90 min and reperfused for 2 h. Lung protein extravasation was measured as (125)I-human albumin accumulation, whereas lung neutrophil infiltration was measured as myeloperoxidase activity. Lung IR in sedentary rats resulted in marked increases in protein extravasation and neutrophil influx, and in significant elevations of serum tumour necrosis factor (TNF)-alpha and interleukin (IL)-1beta levels. Physical preconditioning attenuated the increased IR-induced protein leakage without affecting neutrophil influx. It also reduced serum TNF-alpha (and IL-1beta) levels, but had no effect on IL-10 levels. Plasma superoxide dismutase activity was significantly increased in trained IR rats. The present data show that physical preconditioning protects the rat lung from ischaemia-reperfusion injury by attenuating the pulmonary vascular permeability that may be a consequence of reduced levels of tumour necrosis factor-alpha and interleukin-1beta and elevated superoxide dismutase activity.
Subject: Animals
Disease Models, Animal
Physical Conditioning, Animal
Rats, Wistar
Reperfusion Injury
Respiratory Distress Syndrome, Adult
Citation: The European Respiratory Journal. v. 31, n. 3, p. 645-9, 2008-Mar.
Rights: fechado
Identifier DOI: 10.1183/09031936.00015607
Date Issue: 2008
Appears in Collections:Unicamp - Artigos e Outros Documentos

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