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dc.contributor.CRUESPUNIVERSIDADE DE ESTADUAL DE CAMPINASpt_BR
dc.typeArtigo de periódicopt_BR
dc.titleComparative Study Of Patients With Chronic Hepatitis C Virus Infection Due To Genotypes 1 And 3 Referred For Treatment In Southeast Brazil.pt_BR
dc.contributor.authorVigani, Aline Gpt_BR
dc.contributor.authorPavan, Maria Hpt_BR
dc.contributor.authorTozzo, Raquelpt_BR
dc.contributor.authorGonçales, Eduardo S Lpt_BR
dc.contributor.authorFeltrin, Adrianapt_BR
dc.contributor.authorFais, Viviane Cpt_BR
dc.contributor.authorLazarini, Maria S Kpt_BR
dc.contributor.authorGonçales, Neiva S Lpt_BR
dc.contributor.authorGonçales, Fernando Lpt_BR
unicamp.authorAline G Vigani, Grupo de Estudos das Hepatites Virais, Departamento de Clínica Médica, Faculdade de Ciências Médicas, Universidade Estadual de Campinas - UNICAMP, Sau Paulo, Brasil. aline.vigani@sigmanet.com.brpt_BR
unicamp.author.externalMaria H Pavan,pt
unicamp.author.externalRaquel Tozzo,pt
unicamp.author.externalEduardo S L Gonçales,pt
unicamp.author.externalAdriana Feltrin,pt
unicamp.author.externalViviane C Fais,pt
unicamp.author.externalMaria S K Lazarini,pt
unicamp.author.externalNeiva S L Gonçales,pt
unicamp.author.externalFernando L Gonçales,pt
dc.subjectAdultpt_BR
dc.subjectAgedpt_BR
dc.subjectBrazilpt_BR
dc.subjectFemalept_BR
dc.subjectGenotypept_BR
dc.subjectHepaciviruspt_BR
dc.subjectHepatitis C, Chronicpt_BR
dc.subjectHumanspt_BR
dc.subjectMalept_BR
dc.subjectMiddle Agedpt_BR
dc.subjectTreatment Outcomept_BR
dc.subjectYoung Adultpt_BR
dc.description.abstractThe progression of liver disease in patients with chronic hepatitis C virus (HCV) infection is influenced by host and viral factors. Distinct clinical outcomes in patients infected with different HCV genotypes have been described in the literature. However, the association between specific HCV genotype and clinical outcome remains unclear. We set out to study the natural history of HCV genotype 1 and 3 infections in Campinas, São Paulo state, Brazil, focusing on epidemiological, clinical, biochemical, and histological characteristics. Patients with HCV infection referred for treatment between January 2003 and December 2006 were included in this study. We collected epidemiological, clinical, and laboratorial data using standard forms. A total of 283 patients were included; genotype 1 was identified in 163 (57.6%) patients, genotype 3 in 112 (39.6%), genotype 2 in 7 (2.5%), and genotype 4 in 1 (0.35%). Patients with genotype 2 and 4 were excluded from analysis. Multivariate analysis showed that intravenous energetic drug, positive cryoglobulin, and cirrhosis were independently and significantly associated with HCV genotype 3 (p < 0.05). Genotype 3 currently seems to be associated with intravenous energetic drug, high frequency of cryoglobulinemia, and advanced liver disease in our region. Understanding the distribution of the different HCV genotypes can elucidate transmission of HCV and support optimal prevention strategies.en
dc.relation.ispartofBmc Infectious Diseasespt_BR
dc.relation.ispartofabbreviationBMC Infect. Dis.pt_BR
dc.date.issued2008pt_BR
dc.identifier.citationBmc Infectious Diseases. v. 8, p. 164, 2008.pt_BR
dc.language.isoengpt_BR
dc.description.volume8pt_BR
dc.description.firstpage164pt_BR
dc.rightsabertopt_BR
dc.sourcePubMedpt_BR
dc.identifier.issn1471-2334pt_BR
dc.identifier.doi10.1186/1471-2334-8-164pt_BR
dc.identifier.urlhttp://www.ncbi.nlm.nih.gov/pubmed/19055835pt_BR
dc.date.available2015-11-27T13:13:22Z-
dc.date.accessioned2015-11-27T13:13:22Z-
dc.description.provenanceMade available in DSpace on 2015-11-27T13:13:22Z (GMT). No. of bitstreams: 1 pmed_19055835.pdf: 198043 bytes, checksum: 31b812fc7a3c0ca424f8d0418b98539c (MD5) Previous issue date: 2008en
dc.identifier.urihttp://repositorio.unicamp.br/jspui/handle/REPOSIP/198063-
dc.identifier.idPubmed19055835pt_BR
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