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dc.typeArtigo de periódicopt_BR
dc.titleDistribution Of The Human Leukocyte Antigen Class Ii Alleles In Brazilian Patients With Chronic Hepatitis C Virus Infection.pt_BR
dc.contributor.authorCorghi, D Bpt_BR
dc.contributor.authorGonçales, N S Lpt_BR
dc.contributor.authorMarques, S B Dpt_BR
dc.contributor.authorGonçales Jr, F Lpt_BR
unicamp.authorD B Corghi, Grupo de Estudo das Hepatites, Disciplina de Moléstias Infecciosas, Departamento de Clínica Médica, Faculdade de Ciências Médicas, Universidade Estadual de Campinas, Campinas, SP, Brasil.pt_BR S L Gonçales,pt B D Marques,pt L Gonçales Jr,pt
dc.subjectAntiviral Agentspt_BR
dc.subjectCase-control Studiespt_BR
dc.subjectGene Frequencypt_BR
dc.subjectHla-dq Antigenspt_BR
dc.subjectHla-dq Beta-chainspt_BR
dc.subjectHla-dr Antigenspt_BR
dc.subjectHla-drb1 Chainspt_BR
dc.subjectHepatitis C, Chronicpt_BR
dc.subjectMiddle Agedpt_BR
dc.subjectPolymerase Chain Reactionpt_BR
dc.subjectYoung Adultpt_BR
dc.description.abstractHepatitis C virus (HCV) infection is a global medical problem. The current standard of treatment consists of the combination of peginterferon plus ribavirin. This regimen eradicates HCV in 55% of cases. The immune response to HCV is an important determinant of disease evolution and can be influenced by various host factors. HLA class II may play an important role in immune response against HCV. The objective of the present study was to determine the distribution of HLA class II (DRB1 and DQB1) alleles, their association with chronic HCV infection and their response to interferon therapy. One hundred and two unrelated white Brazilian patients with chronic HCV infection, 52 responders (45 males and 7 females) and 50 non-responders (43 males and 7 females) to antiviral treatment, were included in the study. Healthy Brazilian bone marrow donors of Caucasian origin from the same geographic area constituted the control group (HLA-DRB1, N = 99 and HLA-DQB1, N = 222 individuals). HLA class II genotyping was performed using a low-resolution DRB1, DQB1 sequence-specific primer amplification. There were higher frequencies of HLA-DRB1*13 (26.5 vs 14.1%) and HLA-DQB1*02 (52.9 vs 38.7%) in patients compared with controls; however, these were not significantly different after P correction (Pc = 0.39 and Pc = 0.082, respectively). There was no significant difference between the phenotypic frequencies of HLA-DRB1 (17.3 vs 14.0%) and HLA-DQB1 alleles in responder and non-responder HCV patients. The HLA-DRB1*07 allele was significantly more common in HCV patients (33.3 vs 12.1%) than in controls (Pc = 0.0039), suggesting that the HLA-DRB1*07 allele is associated with chronic HCV infection.en
dc.relation.ispartofBrazilian Journal Of Medical And Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas / Sociedade Brasileira De Biofísica ... [et Al.]pt_BR
dc.relation.ispartofabbreviationBraz. J. Med. Biol. Res.pt_BR
dc.identifier.citationBrazilian Journal Of Medical And Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas / Sociedade Brasileira De Biofísica ... [et Al.]. v. 41, n. 10, p. 884-9, 2008-Oct.pt_BR
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