Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/197744
Type: Artigo de periódico
Title: [hiv Vaginal Viral Load In Brazilian Hiv-infected Women].
Author: Campos, Angela
Amaral, Eliana
Levi, José Eduardo
Portugal, Priscila
Villarroel, Marina
Bezerra, Karina C
Silva, Marcos T Nolasco da
Morais, Sirlei Siani
Abstract: To evaluate factors associated to presence of free RNA-HIV in the vagina. Cross-sectional study with HIV-infected women, excluding those who had undergone hysterectomy, had used vaginal medication within the last 48 hours, had had unprotected sex less than 72 hours before, were pregnant, or had genital bleeding. After signing an informed consent, blood samples were obtained for T CD4 lymphocytes count and plasmatic viral load, in addition to cervico-vaginal lavage using 10 mL of sterile normal saline, later centrifuged, aliquoted and stored at - 70 degrees C to quantify free HIV-RNA. Plasmatic and vaginal viral load were measured using the kit HIV Monitor v1.5 Cobas Amplicor, Roche. Hybrid Capture test Digene was utilized for HPV (high and low risk), chlamydia trachomatis and N. gonorrhoea detection from an endocervical sample. Vaginal swab for bacterioscopy by the Gram method, evaluated according to Nugent criteria was obtained. Among 200 women evaluated, 73.5% were using HAART. The RNA-HIV was detectable in the vaginal lavage of 18 (9%), but in only one of those who had undetectable plasma viral load (0.5%). The vaginal prevalence of HIV was 24 times higher among those with detectable plasmatic HIV. Plasma viral load > 1500 copies/mL, no HAART use, reduced CD4 and bacterial vaginosis had increased prevalence of vaginal HIV-RNA, but in the adjusted statistical analysis, only the former remained significant Prevalence of vaginal HIV-RNA was low (9%). Plasmatic viral load > 1500 copies/mL, was the only risk factor for free vaginal HIV-RNA.
Subject: Adult
Analysis Of Variance
Anti-hiv Agents
Cd4 Lymphocyte Count
Cross-sectional Studies
Female
Hiv Infections
Hiv-1
Humans
Rna, Viral
Statistics, Nonparametric
Vagina
Vaginal Smears
Viral Load
Citation: Revista Da Associação Médica Brasileira (1992). v. 54, n. 1, p. 67-71
Rights: fechado
Address: http://www.ncbi.nlm.nih.gov/pubmed/18392489
Appears in Collections:Unicamp - Artigos e Outros Documentos

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