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Type: Artigo de periódico
Title: Mri Shows Dorsal Lesions And Spinal Cord Atrophy In Chronic Sensory Neuronopathies.
Author: França, Marcondes C
D'Abreu, Anelyssa
Zanardi, Verônica A
Faria, Andréia V
Lopes-Cendes, Iscia
Nucci, Anamarli
Cendes, Fernando
Abstract: Sensory neuronopathies (SN) represent a specific subgroup of peripheral nervous system diseases, characterized by degeneration of dorsal root ganglia (DRG) and its projections. We tried to estimate the frequency and extent of spinal cord MRI abnormalities in a group of patients with SN and correlate these with clinical and neurophysiological features. We performed spinal cord MRI scans in 16 chronic SN patients. Images were analyzed for the presence of posterior hyperintense lesions on T2WI and cord areas at C3 level were obtained using a previously validated method. A group of 14 healthy controls with similar age and gender distribution was used for comparison. ANOVA was employed for statistical analysis. Posterior T2WI lesions were found in 13 out of 16 patients. Cord areas were significantly smaller in SN patients than controls (84.3 x 97.2 mm(2), P < .05). Atrophy correlated with severity of sensory ataxia and neurophysiologic abnormalities but not with duration of disease. These findings support volumetric spinal cord MRI as a useful tool in the assessment of chronic SN.
Subject: Analysis Of Variance
Case-control Studies
Chronic Disease
Hereditary Sensory And Autonomic Neuropathies
Image Processing, Computer-assisted
Linear Models
Magnetic Resonance Imaging
Middle Aged
Spinal Cord
Citation: Journal Of Neuroimaging : Official Journal Of The American Society Of Neuroimaging. v. 18, n. 2, p. 168-72, 2008-Apr.
Rights: fechado
Identifier DOI: 10.1111/j.1552-6569.2007.00193.x
Date Issue: 2008
Appears in Collections:Unicamp - Artigos e Outros Documentos

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